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Human acute inflammatory recovery is defined by co-regulatory dynamics of white blood cell and platelet populations.
Foy, Brody H; Sundt, Thoralf M; Carlson, Jonathan C T; Aguirre, Aaron D; Higgins, John M.
  • Foy BH; Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Sundt TM; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Carlson JCT; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
  • Aguirre AD; Division of Cardiac Surgery, Corrigan Minehan Heart Center, Massachusetts General Hospital, Boston, MA, USA.
  • Higgins JM; Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. carlson.jonathan@mgh.harvard.edu.
Nat Commun ; 13(1): 4705, 2022 08 22.
Article in English | MEDLINE | ID: covidwho-2000883
ABSTRACT
Inflammation is the physiologic reaction to cellular and tissue damage caused by trauma, ischemia, infection, and other pathologic conditions. Elevation of white blood cell count (WBC) and altered levels of other acute phase reactants are cardinal signs of inflammation, but the dynamics of these changes and their resolution are not well established. Here we studied inflammatory recovery from trauma, ischemia, and infection by tracking longitudinal dynamics of clinical laboratory measurements in hospitalized patients. We identified a universal recovery trajectory defined by exponential WBC decay and delayed linear growth of platelet count (PLT). Co-regulation of WBC-PLT dynamics is a fundamental mechanism of acute inflammatory recovery and provides a generic approach for identifying high-risk patients 32x relative risk (RR) of adverse outcomes for cardiac surgery, 9x RR of death from COVID-19, 9x RR of death from sepsis, and 5x RR of death from myocardial infarction.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-32222-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-32222-2