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Designing isolation guidelines for COVID-19 patients with rapid antigen tests.
Jeong, Yong Dam; Ejima, Keisuke; Kim, Kwang Su; Joohyeon, Woo; Iwanami, Shoya; Fujita, Yasuhisa; Jung, Il Hyo; Aihara, Kazuyuki; Shibuya, Kenji; Iwami, Shingo; Bento, Ana I; Ajelli, Marco.
  • Jeong YD; interdisciplinary Biology Laboratory (iBLab), Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan.
  • Ejima K; Department of Mathematics, Pusan National University, Busan, South Korea.
  • Kim KS; Department of Epidemiology and Biostatistics, Indiana University School of Public Health-Bloomington, Bloomington, IN, USA. kejima@iu.edu.
  • Joohyeon W; The Tokyo Foundation for Policy Research, Tokyo, Japan. kejima@iu.edu.
  • Iwanami S; interdisciplinary Biology Laboratory (iBLab), Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan.
  • Fujita Y; Department of Scientific computing, Pukyong National University, Busan, South Korea.
  • Jung IH; interdisciplinary Biology Laboratory (iBLab), Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan.
  • Aihara K; interdisciplinary Biology Laboratory (iBLab), Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan.
  • Shibuya K; interdisciplinary Biology Laboratory (iBLab), Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan.
  • Iwami S; Department of Mathematics, Pusan National University, Busan, South Korea.
  • Bento AI; International Research Center for Neurointelligence, The University of Tokyo, Tokyo, Japan.
  • Ajelli M; The Tokyo Foundation for Policy Research, Tokyo, Japan.
Nat Commun ; 13(1): 4910, 2022 08 20.
Article in English | MEDLINE | ID: covidwho-2000889
ABSTRACT
Appropriate isolation guidelines for COVID-19 patients are warranted. Currently, isolating for fixed time is adopted in most countries. However, given the variability in viral dynamics between patients, some patients may no longer be infectious by the end of isolation, whereas others may still be infectious. Utilizing viral test results to determine isolation length would minimize both the risk of prematurely ending isolation of infectious patients and the unnecessary individual burden of redundant isolation of noninfectious patients. In this study, we develop a data-driven computational framework to compute the population-level risk and the burden of different isolation guidelines with rapid antigen tests (i.e., lateral flow tests). Here, we show that when the detection limit is higher than the infectiousness threshold values, additional consecutive negative results are needed to ascertain infectiousness status. Further, rapid antigen tests should be designed to have lower detection limits than infectiousness threshold values to minimize the length of prolonged isolation.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-32663-9

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-32663-9