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Supratherapeutic Tacrolimus Concentrations With Nirmatrelvir/Ritonavir in Solid Organ Transplant Recipients Requiring Hospitalization: A Case Series Using Rifampin for Reversal.
Rose, Dusten T; Gandhi, Saurin M; Bedard, Rachael A; Mondy, Kristin E; Chu, Alexander L; Gamble, Kelly C; Gee, Amanda T; Kundra, Monica A; Williams, Amber L; Lee, Brian K.
  • Rose DT; Department of Pharmacy, Ascension Seton, Dell Seton Medical at The University of Texas, Austin, Texas, USA.
  • Gandhi SM; Department of Internal Medicine, Dell Medical School, University of Texas at Austin, Austin, Texas, USA.
  • Bedard RA; Department of Pharmacy, Ascension Seton, Dell Seton Medical at The University of Texas, Austin, Texas, USA.
  • Mondy KE; Division of Infectious Diseases, Department of Internal Medicine, Dell Medical School, University of Texas at Austin, Austin, Texas, USA.
  • Chu AL; Department of Medical Education, Dell Medical School, University of Texas at Austin, Austin, Texas, USA.
  • Gamble KC; Department of Pharmacy, Ascension Seton, Dell Seton Medical at The University of Texas, Austin, Texas, USA.
  • Gee AT; Department of Pharmacy, Ascension Seton, Dell Seton Medical at The University of Texas, Austin, Texas, USA.
  • Kundra MA; Department of Internal Medicine, Dell Medical School, University of Texas at Austin, Austin, Texas, USA.
  • Williams AL; Department of Pharmacy, Ascension Seton, Dell Seton Medical at The University of Texas, Austin, Texas, USA.
  • Lee BK; Kidney and Pancreas Transplant Program, Dell Seton Medical Center, University of Texas at Austin, Austin, Texas, USA.
Open Forum Infect Dis ; 9(7): ofac238, 2022 Jul.
Article in English | MEDLINE | ID: covidwho-2001400
ABSTRACT
Nirmatrelvir/ritonavir was recently granted emergency use authorization for mild to moderate coronavirus disease 2019. Drug-drug interactions between ritonavir and tacrolimus are underappreciated by nontransplant providers. We describe 2 solid organ transplant recipients prescribed nirmatrelvir/ritonavir for outpatient use who developed tacrolimus toxicity requiring hospitalization and were managed with rifampin for toxicity reversal.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report Language: English Journal: Open Forum Infect Dis Year: 2022 Document Type: Article Affiliation country: Ofid

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report Language: English Journal: Open Forum Infect Dis Year: 2022 Document Type: Article Affiliation country: Ofid