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Pilot study for immunoglobulin E as a prognostic biomarker in coronavirus disease 2019.
Aydin Guclu, Ozge; Goktas, Seda S; Gorek Dilektasli, Asli; Acet Ozturk, Nilufer A; Demirdogen, Ezgi; Coskun, Funda; Ediger, Dane; Ursavas, Ahmet; Uzaslan, Esra; Erol, Hasim A; Karacay, Nurdan D; Kaya Sel, Umut; Karadag, Mehmet.
  • Aydin Guclu O; Department of Pulmonary Diseases, Uludag University Faculty of Medicine, Bursa, Turkey.
  • Goktas SS; Department of Pulmonary Disease, Boyabat 75th Year State Hospital, Sinop, Turkey.
  • Gorek Dilektasli A; Department of Otolaryngology, Boyabat 75th Year State Hospital, Sinop, Turkey.
  • Acet Ozturk NA; Department of Pulmonary Diseases, Uludag University Faculty of Medicine, Bursa, Turkey.
  • Demirdogen E; Department of Pulmonary Diseases, Uludag University Faculty of Medicine, Bursa, Turkey.
  • Coskun F; Department of Pulmonary Diseases, Uludag University Faculty of Medicine, Bursa, Turkey.
  • Ediger D; Department of Pulmonary Diseases, Uludag University Faculty of Medicine, Bursa, Turkey.
  • Ursavas A; Department of Pulmonary Diseases, Section of Immunology and Allergy Diseases, Uludag University Faculty of Medicine, Bursa, Turkey.
  • Uzaslan E; Department of Pulmonary Diseases, Uludag University Faculty of Medicine, Bursa, Turkey.
  • Erol HA; Department of Pulmonary Diseases, Uludag University Faculty of Medicine, Bursa, Turkey.
  • Karacay ND; Department of Internal Medicine, Boyabat 75th Year State Hospital, Sinop, Turkey.
  • Kaya Sel U; Department of Internal Medicine, Boyabat 75th Year State Hospital, Sinop, Turkey.
  • Karadag M; Department of Anesthesiology and Intensive Care, Boyabat 75th Year State Hospital, Sinop, Turkey.
Intern Med J ; 52(9): 1495-1504, 2022 09.
Article in English | MEDLINE | ID: covidwho-2001643
ABSTRACT

BACKGROUND:

Laboratory biomarkers to estimate the severity of coronavirus disease 2019 (COVID-19) are crucial during the pandemic since resource allocation must be carefully planned.

AIMS:

To evaluate the effects of basal serum total immunoglobulin E (IgE) levels and changes in inflammatory parameters on the clinical progression of patients hospitalised with COVID-19.

METHODS:

Patients hospitalised with confirmed COVID-19 were included in the study. Laboratory data and total IgE levels were measured on admission. Lymphocyte, eosinophil, ferritin, d-dimer and C-reactive protein parameters were recorded at baseline and on the 3rd and 14th days of hospitalisation.

RESULTS:

The study enrolled 202 patients, of which 102 (50.5%) were males. The average age was 50.17 ± 19.68 years. Of the COVID-19 patients, 41 (20.3%) showed clinical progression. Serum total IgE concentrations were markedly higher (172.90 (0-2124) vs 38.70 (0-912); P < 0.001) and serum eosinophil levels were significantly lower (0.015 (0-1.200) vs 0.040 (0-1.360); P = 0.002) in clinically worsened COVID-19 patients when compared with stable patients. The optimal cut-off for predicting clinical worsening was 105.2 ng/L, with 61% sensitivity, 82% specificity, 46.3% positive predictive value and 89.2% negative predictive value (area under the curve = 0.729). Multivariable analysis to define risk factors for disease progression identified higher total IgE and C-reactive protein levels as independent predictors.

CONCLUSIONS:

Our single-centre pilot study determined that total IgE levels may be a negative prognostic factor for clinical progression in patients hospitalised due to COVID-19 infection. Future studies are required to determine the impact of individuals' underlying immune predispositions on outcomes of COVID-19 infections.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Intern Med J Journal subject: Internal Medicine Year: 2022 Document Type: Article Affiliation country: Imj.15728

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Intern Med J Journal subject: Internal Medicine Year: 2022 Document Type: Article Affiliation country: Imj.15728