Your browser doesn't support javascript.
Study of common hypertriglyceridaemia genetic variants and subclinical atherosclerosis in a group of women with SLE and a control group.
Fanlo-Maresma, Marta; Esteve-Luque, Virginia; Pintó, Xavier; Padró-Miquel, Ariadna; Corbella, Emili; Candás-Estébanez, Beatriz.
  • Fanlo-Maresma M; Vascular Risk Unit, Internal Medicine Department, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain.
  • Esteve-Luque V; Vascular Risk Unit, Internal Medicine Department, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain.
  • Pintó X; Vascular Risk Unit, Internal Medicine Department, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain xpinto@bellvitgehospital.cat.
  • Padró-Miquel A; Vascular Risk Unit, Internal Medicine Department, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain.
  • Corbella E; Vascular Risk Unit, Internal Medicine Department, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain.
  • Candás-Estébanez B; Vascular Risk Unit, Internal Medicine Department, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain.
Lupus Sci Med ; 9(1)2022 08.
Article in English | MEDLINE | ID: covidwho-2001886
ABSTRACT

OBJECTIVE:

SLE is associated with increased cardiovascular risk (CVR). High serum concentrations of triglyceride-rich lipoproteins and apolipoprotein B-rich particles constitute the characteristic dyslipidaemia of SLE.

METHODS:

A cross-sectional study was conducted to study the relationship between genetic variants involved in polygenic hypertriglyceridaemia, subclinical atherosclerosis and lipoprotein abnormalities. 73 women with SLE and 73 control women age-matched with the case group were recruited (age range 30-75 years). Serum analysis, subclinical atherosclerosis screening studies for the detection of plaque, and genetic analysis of the APOE, ZPR1, APOA5 and GCKR genes were performed.

RESULTS:

Triglyceride concentrations and the prevalence of hypertension, dyslipidaemia and carotid atherosclerosis were higher in women with SLE than in the control group. Multivariate logistic regression showed that CC homozygosity for the GCKR rs1260326 gene (OR=0.111, 95% CI 0.015 to 0.804, p=0.030) and an increase of 1 mmol/L in triglyceride concentrations were associated with a greater risk of carotid plaque in women with SLE (OR=7.576, 95% CI 2.415 to 23.767, p=0.001).

CONCLUSIONS:

GCKR CC homozygosity (rs1260326) and serum triglyceride concentrations are independently associated with subclinical carotid atherosclerosis in women with SLE. Subclinical carotid atherosclerosis is also more prevalent in these women compared with the control group. The study of GCKR rs1260326 gene variants may contribute to more precise assessment of CVR and modulation of the intensity of lipid-lowering treatment in patients with SLE.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Hypertriglyceridemia / Carotid Artery Diseases / Atherosclerosis / Dyslipidemias / Plaque, Atherosclerotic / Lupus Erythematosus, Systemic Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid / Variants Limits: Adult / Aged / Female / Humans / Middle aged Language: English Year: 2022 Document Type: Article Affiliation country: Lupus-2022-000774

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Hypertriglyceridemia / Carotid Artery Diseases / Atherosclerosis / Dyslipidemias / Plaque, Atherosclerotic / Lupus Erythematosus, Systemic Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid / Variants Limits: Adult / Aged / Female / Humans / Middle aged Language: English Year: 2022 Document Type: Article Affiliation country: Lupus-2022-000774