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Incidence of Stroke in Randomized Trials of COVID-19 Therapeutics: A Systematic Review and Meta-Analysis.
Nagraj, Sanjana; Varrias, Dimitrios; Hernandez Romero, Gabriel; Santos, Heitor T; Karamanis, Dimitrios; Sagris, Dimitrios; Korompoki, Eleni; Milionis, Haralampos; Palaiodimos, Leonidas; Ntaios, George.
  • Nagraj S; Jacobi Medical Center/Albert Einstein College of Medicine, The Bronx, NY (S.N., D.V., G.H.R., H.T.S., L.P.).
  • Varrias D; Jacobi Medical Center/Albert Einstein College of Medicine, The Bronx, NY (S.N., D.V., G.H.R., H.T.S., L.P.).
  • Hernandez Romero G; Jacobi Medical Center/Albert Einstein College of Medicine, The Bronx, NY (S.N., D.V., G.H.R., H.T.S., L.P.).
  • Santos HT; Jacobi Medical Center/Albert Einstein College of Medicine, The Bronx, NY (S.N., D.V., G.H.R., H.T.S., L.P.).
  • Karamanis D; Department of Economics, University of Piraeus, Greece (D.K.).
  • Sagris D; Department of Health Informatics, Rutgers School of Health Professions, Newark, NJ (D.K.).
  • Korompoki E; School of Health Sciences, University of Thessaly, Larissa, Greece (D.S.).
  • Milionis H; National and Kapodistrian University of Athens, Alexandra General Hospital, Greece & Imperial College London, Exhibition Rd, South Kensington, London SW7 2BX, United Kingdom (E.K.).
  • Palaiodimos L; School of Health Sciences, University of Ioannina, Greece (H.M.).
  • Ntaios G; Jacobi Medical Center/Albert Einstein College of Medicine, The Bronx, NY (S.N., D.V., G.H.R., H.T.S., L.P.).
Stroke ; 53(11): 3410-3418, 2022 11.
Article in English | MEDLINE | ID: covidwho-2002000
ABSTRACT

BACKGROUND:

COVID-19 has been frequently associated with an increased risk of thrombotic complications. There have also been reports of an increased likelihood of stroke, although its true incidence in patients with COVID-19 is currently unknown.

METHODS:

Electronic databases PubMed and Scopus were searched from inception up to July 30, 2021 to identify randomized controlled studies in patients with confirmed COVID-19 undergoing one or more interventions. Studies were screened for eligibility using a predefined inclusion criterion and selected using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A random-effects model meta-analysis was conducted, and heterogeneity was assessed using I-squared test.

RESULTS:

Out of 3960 potentially eligible articles, 77 randomized studies (38 732 patients) were included. Mean age of the study population was 55±9.3 years. Females constituted 38% of the study population and mean duration of follow-up after study enrollment was 23±12.9 days. Cumulative incidence of stroke in the overall study population was 0.001 (95% CI, 0.001-0.002) with a total of 65 events in 38 732 patients, corresponding to an absolute incidence of 0.168%. Incidence of stroke in the inpatient population was 0.001 (95% CI, 0.001-0.002; 65 events in 37 069 patients), corresponding to an absolute incidence of 0.175%. No strokes were observed in the outpatient setting.

CONCLUSIONS:

The overall incidence of stroke in patients with COVID-19 appears to be lower than that reported in previous observational reports.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Stroke / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Female / Humans / Middle aged Language: English Journal: Stroke Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Stroke / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Female / Humans / Middle aged Language: English Journal: Stroke Year: 2022 Document Type: Article