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Advances in Crosstalk between Porcine Circoviruses and Host.
Niu, Guyu; Chen, Si; Li, Xue; Zhang, Liying; Ren, Linzhu.
  • Niu G; Key Laboratory for Zoonoses Research, Ministry of Education, College of Animal Sciences, Jilin University, 5333 Xi'an Road, Changchun 130062, China.
  • Chen S; Key Laboratory for Zoonoses Research, Ministry of Education, College of Animal Sciences, Jilin University, 5333 Xi'an Road, Changchun 130062, China.
  • Li X; Key Laboratory for Zoonoses Research, Ministry of Education, College of Animal Sciences, Jilin University, 5333 Xi'an Road, Changchun 130062, China.
  • Zhang L; Key Laboratory for Zoonoses Research, Ministry of Education, College of Animal Sciences, Jilin University, 5333 Xi'an Road, Changchun 130062, China.
  • Ren L; Key Laboratory for Zoonoses Research, Ministry of Education, College of Animal Sciences, Jilin University, 5333 Xi'an Road, Changchun 130062, China.
Viruses ; 14(7)2022 06 28.
Article in English | MEDLINE | ID: covidwho-2002547
ABSTRACT
Porcine circoviruses (PCVs), including PCV1 to PCV4, are non-enveloped DNA viruses with a diameter of about 20 nm, belonging to the genus Circovirus in the family Circoviridae. PCV2 is an important causative agent of porcine circovirus disease or porcine circovirus-associated disease (PCVD/PCVAD), which is highly prevalent in pigs and seriously affects the swine industry globally. Furthermore, PCV2 mainly causes subclinical symptoms and immunosuppression, and PCV3 and PCV4 were detected in healthy pigs, sick pigs, and other animals. Although the pathogenicity of PCV3 and PCV4 in the field is still controversial, the infection rates of PCV3 and PCV4 in pigs are increasing. Moreover, PCV3 and PCV4 rescued from infected clones were pathogenic in vivo. It is worth noting that the interaction between virus and host is crucial to the infection and pathogenicity of the virus. This review discusses the latest research progress on the molecular mechanism of PCVs-host interaction, which may provide a scientific basis for disease prevention and control.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Swine Diseases / Circovirus / Circoviridae Infections Type of study: Randomized controlled trials Limits: Animals Language: English Year: 2022 Document Type: Article Affiliation country: V14071419

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Swine Diseases / Circovirus / Circoviridae Infections Type of study: Randomized controlled trials Limits: Animals Language: English Year: 2022 Document Type: Article Affiliation country: V14071419