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Pharmacological protection of vascular endothelium in acute COVID-19.
Bednarz, K; Borek, A; Drzymala, F; Rachwal, K; Gabryel, B.
  • Bednarz K; Students' Scientific Society at Department of Pharmacology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
  • Borek A; Students' Scientific Society at Department of Pharmacology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
  • Drzymala F; Students' Scientific Society at Department of Pharmacology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
  • Rachwal K; Students' Scientific Society at Department of Pharmacology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
  • Gabryel B; Department of Pharmacology, School of Medicine in Katowice, Medical University, Katowice, Poland. bgabryel@sum.edu.pl.
J Physiol Pharmacol ; 73(2)2022 Apr.
Article in English | MEDLINE | ID: covidwho-2002832
ABSTRACT
Since the beginning of the COVID-19 pandemic, there has been an urgent need to find effective treatment. It is widely known that virus attacks and damages mostly the lungs, but also infect vascular endothelial cells. Therefore, the protection of the endothelium is a promising target in the therapy of COVID-19 and its complications. In this review article, we focused on several groups of drugs with potential to protect the endothelium. The most promising ones are angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, drugs targeting angiotensin-converting enzyme 2, heparins, sulodexide, acetylsalicylic acid, statins, tocilizumab, baricitinib, and defibrotide. Although the short period of trials and the lack of data necessitate further research, endothelial protection remains a promising target for COVID-19 therapy.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Drug Treatment Type of study: Experimental Studies / Randomized controlled trials Limits: Humans Language: English Journal subject: Pharmacology / Physiology Year: 2022 Document Type: Article Affiliation country: Jpp.2022.2.01

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Drug Treatment Type of study: Experimental Studies / Randomized controlled trials Limits: Humans Language: English Journal subject: Pharmacology / Physiology Year: 2022 Document Type: Article Affiliation country: Jpp.2022.2.01