Your browser doesn't support javascript.
Study on the Mucosal and Serological Immune Response to the Novel Coronavirus(SARS-CoV- 2) Vaccines
Hong Kong Journal of Paediatrics ; 27(1):67, 2022.
Article in English | EMBASE | ID: covidwho-2003052
ABSTRACT
Vaccines that elicit mucosal immune responses against SARS-CoV-2 could potent ially be of exceptional importance in providing first line defence at the site of viral entry. In order to understand the mucosal immune response profiles of SARS-CoV-2 vaccines, we examined both the mucosal and systemic responses of subjects vaccinated by two different vaccination platforms mRNA (Comirnaty) and inactivated virus (CoronaVac). Nasal epithelial lining fluid (NELF) and peripheral blood samples were collected in subjects who had received two doses of CoronaVac or Comirnaty. We quantified IgA and IgG specific to SARS-CoV-2 S1 protein, neutralisation antibody by ELISA in NELF and plasma samples. Only Comirnaty induced nasal S1-specific IgA and IgG responses, which were evident as early as on 14±2 days after the first dose. The NELF samples of 72% of subjects became IgA+IgG+, while in 62.5% of subjects the samples were neutralising by 7±2 days after the second dose. In 45% of the subjects their NELF remained neutralising 50 days after the booster. In plasma, 91% and 100% Comirnaty subjects possessed S1-specific IgA+IgG+ on 14±2 days after the first dose and 7±2 days after booster, respectively. The plasma collected on 7±2 days after booster was 100% neutralising. The induction of S1-specific antibody by CoronaVac was IgG dominant, and 70% of the subjects possessed specific IgG by 7±2 days after booster and were all neutralising. This study reveals that Comirnaty is able to induce S1-specific IgA and IgG r esponse with neutralising activity in the nasal mucosa in addition to a consistent systemic response.
Keywords
Search on Google
Collection: Databases of international organizations Database: EMBASE Topics: Vaccines Language: English Journal: Hong Kong Journal of Paediatrics Year: 2022 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS

Search on Google
Collection: Databases of international organizations Database: EMBASE Topics: Vaccines Language: English Journal: Hong Kong Journal of Paediatrics Year: 2022 Document Type: Article