Ex situ-armus: experimental models for combating respiratory dysfunction.
Curr Opin Genet Dev
; 75: 101946, 2022 08.
Article
in English
| MEDLINE | ID: covidwho-2004086
ABSTRACT
Ex situ experimental models have become a main stay in pulmonary research. Organoids and explant systems have uncovered novel stem cell subsets, served as disease models, delineated cell fate transitions, and aided high throughput pre-clinical drug screening. Integration of gene-editing and bioengineering approaches have further generated novel avenues for regenerative medicine and transplantation strategies. In this article, we highlight recent studies, aided by ex situ systems, which have contributed to significant advances in our understanding of the human lower respiratory tract. We present key observations from these studies to gain improved insights into human disease. We conclude this article with a summary of existing challenges and potential technological advances to successfully mirror human tissue physiology.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Organoids
/
Regenerative Medicine
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Curr Opin Genet Dev
Journal subject:
Genetics
Year:
2022
Document Type:
Article
Affiliation country:
J.gde.2022.101946
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