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Cystatin C is associated with adverse COVID-19 outcomes in diverse populations.
Kleeman, Sam O; Cordioli, Mattia; Timmers, Paul R H J; Khan, Atlas; Tober-Lau, Pinkus; Kurth, Florian; Demichev, Vadim; Meyer, Hannah V; Wilson, James F; Ralser, Markus; Kiryluk, Krzysztof; Ganna, Andrea; Baillie, Kenneth; Janowitz, Tobias.
  • Kleeman SO; Cold Spring Harbor Laboratory, Cold Spring Harbor, One Bungtown Road, New York, NY 11724, USA.
  • Cordioli M; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
  • Timmers PRHJ; MRC Human Genetics Unit, MRC Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
  • Khan A; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
  • Tober-Lau P; Division of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA.
  • Kurth F; Department of Biochemistry, Charité - Universitätsmedizin Berlin, Germany.
  • Demichev V; Department of Biochemistry, Charité - Universitätsmedizin Berlin, Germany.
  • Meyer HV; Department of Biochemistry, Charité - Universitätsmedizin Berlin, Germany.
  • Wilson JF; Cold Spring Harbor Laboratory, Cold Spring Harbor, One Bungtown Road, New York, NY 11724, USA.
  • Ralser M; MRC Human Genetics Unit, MRC Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
  • Kiryluk K; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
  • Ganna A; Department of Biochemistry, Charité - Universitätsmedizin Berlin, Germany.
  • Baillie K; Division of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA.
  • Janowitz T; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
iScience ; 25(10): 105040, 2022 Oct 21.
Article in English | MEDLINE | ID: covidwho-2004160
ABSTRACT
COVID-19 has highly variable clinical courses. The search for prognostic host factors for COVID-19 outcome is a priority. We performed logistic regression for ICU admission against a polygenic score (PGS) for Cystatin C (CyC) production in patients with COVID-19. We analyzed the predictive value of longitudinal plasma CyC levels in an independent cohort of patients hospitalized with COVID-19. In four cohorts spanning European and African ancestry populations, we identified a significant association between CyC-production PGS and odds of critical illness (n cases=2,319), with the strongest association captured in the UKB cohort (OR 2.13, 95% CI 1.58-2.87, p=7.12e-7). Plasma proteomics from an independent cohort of hospitalized COVID-19 patients (n cases = 131) demonstrated that CyC production was associated with COVID-specific mortality (p=0.0007). Our findings suggest that CyC may be useful for stratification of patients and it has functional role in the host response to COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Journal: IScience Year: 2022 Document Type: Article Affiliation country: J.isci.2022.105040

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Journal: IScience Year: 2022 Document Type: Article Affiliation country: J.isci.2022.105040