Association of Multiple Sclerosis and COVID-19 Infection: A Case Report
Multiple Sclerosis and Related Disorders
; 59, 2022.
Article
in English
| EMBASE | ID: covidwho-2004361
ABSTRACT
Introduction:
Since the declaration of COVID-19 pandemic, several cases of demyelination of both peripheral and central nervous systems have been reported. The association of viral infection and the development of CNS demyelination has long been studied, and this link has recently been reported following SARS-CoV-2 infection as well. Material(s) and Method(s) We report a case of a 36-year-old male who developed CNS demyelinating disease, that fulfilled the diagnostic criteria of multiple sclerosis (MS), 2 months after laboratory-confirmed infection with SARS-CoV-2. Result(s) A 36-year-old male developed CNS demyelination, 2-months following a laboratory-confirmed SARS-CoV-2 infection, that fulfilled the revised 2017 McDonald diagnostic criteria for MS. He presented with ataxia, and MRI showed multiple demyelinating lesions in the brain, and positive oligoclonal bands in CSF. Conclusion(s) To our knowledge, this is the second case report of MS in association with COVID-19 infection, and the first case from Middle East and North Africa (MENA) region. This case report adds to the growing body of evidence of a probable causal relationship between SARS‐CoV‐2 infection and the development of MS. SARS-CoV-2 could potentially trigger a demyelinating process, through an acute or delayed immune-mediated CNS inflammatory response.
endogenous compound; oligoclonal band; adult; ataxia; case report; central nervous system; cerebrospinal fluid; clinical article; conference abstract; coronavirus disease 2019; demyelinating disease; diagnosis; genetic susceptibility; human; inflammation; male; Middle East; multiple sclerosis; neuroimaging; nonhuman; North Africa; nuclear magnetic resonance imaging; Severe acute respiratory syndrome coronavirus 2
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Case report
Language:
English
Journal:
Multiple Sclerosis and Related Disorders
Year:
2022
Document Type:
Article
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