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Pre-existing SARS-CoV-2 immunity influences potency, breadth, and durability of the humoral response to SARS-CoV-2 vaccination.
Mantus, Grace; Nyhoff, Lindsay E; Edara, Venkata-Viswanadh; Zarnitsyna, Veronika I; Ciric, Caroline R; Flowers, Maria W; Norwood, Carson; Ellis, Madison; Hussaini, Laila; Manning, Kelly E; Stephens, Kathy; Anderson, Evan J; Ahmed, Rafi; Suthar, Mehul S; Wrammert, Jens.
  • Mantus G; Department of Pediatrics, Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta and Emory University, Atlanta, GA 30329, USA; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30329, USA; Division of Infectious Diseases, Department of Pediatrics, Emory
  • Nyhoff LE; Department of Pediatrics, Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta and Emory University, Atlanta, GA 30329, USA; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30329, USA; Division of Infectious Diseases, Department of Pediatrics, Emory
  • Edara VV; Department of Pediatrics, Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta and Emory University, Atlanta, GA 30329, USA; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30329, USA; Division of Infectious Diseases, Department of Pediatrics, Emory
  • Zarnitsyna VI; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
  • Ciric CR; Department of Pediatrics, Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta and Emory University, Atlanta, GA 30329, USA; Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
  • Flowers MW; Department of Pediatrics, Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta and Emory University, Atlanta, GA 30329, USA; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30329, USA; Division of Infectious Diseases, Department of Pediatrics, Emory
  • Norwood C; Department of Pediatrics, Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta and Emory University, Atlanta, GA 30329, USA; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30329, USA; Division of Infectious Diseases, Department of Pediatrics, Emory
  • Ellis M; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30329, USA; Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA; Yerkes National Primate Research Center, Atlanta, GA 30329, USA.
  • Hussaini L; Department of Pediatrics, Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta and Emory University, Atlanta, GA 30329, USA; Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
  • Manning KE; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30329, USA; Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA; Yerkes National Primate Research Center, Atlanta, GA 30329, USA.
  • Stephens K; Department of Pediatrics, Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta and Emory University, Atlanta, GA 30329, USA; Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
  • Anderson EJ; Department of Pediatrics, Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta and Emory University, Atlanta, GA 30329, USA; Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA; Department of Medicine, Emory Univ
  • Ahmed R; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
  • Suthar MS; Department of Pediatrics, Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta and Emory University, Atlanta, GA 30329, USA; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30329, USA; Division of Infectious Diseases, Department of Pediatrics, Emory
  • Wrammert J; Department of Pediatrics, Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta and Emory University, Atlanta, GA 30329, USA; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30329, USA; Division of Infectious Diseases, Department of Pediatrics, Emory
Cell Rep Med ; 3(4): 100603, 2022 04 19.
Article in English | MEDLINE | ID: covidwho-2004611
ABSTRACT
The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic highlights the importance of determining the breadth and durability of humoral immunity to SARS-CoV-2 mRNA vaccination. Herein, we characterize the humoral response in 27 naive and 40 recovered vaccinees. SARS-CoV-2-specific antibody and memory B cell (MBC) responses are durable up to 6 months, although antibody half-lives are shorter for naive recipients. The magnitude of the humoral responses to vaccination strongly correlates with responses to initial SARS-CoV-2 infection. Neutralization titers are lower against SARS-CoV-2 variants in both recovered and naive vaccinees, with titers more reduced in naive recipients. While the receptor-binding domain (RBD) is the main neutralizing target of circulating antibodies, Moderna-vaccinated naives show a lesser reliance on RBDs, with >25% neutralization remaining after depletion of RBD-binding antibodies. Overall, we observe that vaccination induces higher peak titers and improves durability in recovered compared with naive vaccinees. These findings have broad implications for current vaccine strategies deployed against the SARS-CoV-2 pandemic.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Vaccines / COVID-19 Topics: Vaccines / Variants Limits: Humans Language: English Journal: Cell Rep Med Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Vaccines / COVID-19 Topics: Vaccines / Variants Limits: Humans Language: English Journal: Cell Rep Med Year: 2022 Document Type: Article