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Vaccine subtype and dose interval determine immunogenicity of primary series COVID-19 vaccines in older people.
Parry, Helen; Bruton, Rachel; Ayodele, Reni; Sylla, Penny; McIlroy, Graham; Logan, Nicola; Scott, Sam; Nicol, Sam; Verma, Kriti; Stephens, Christine; Willett, Brian; Zuo, Jianmin; Moss, Paul.
  • Parry H; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK.
  • Bruton R; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK.
  • Ayodele R; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK.
  • Sylla P; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK.
  • McIlroy G; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham B15 2TT, UK.
  • Logan N; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK.
  • Scott S; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK.
  • Nicol S; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK.
  • Verma K; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK.
  • Stephens C; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK.
  • Willett B; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK.
  • Zuo J; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK.
  • Moss P; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK. Electronic address: P.Moss@bham.ac.uk.
Cell Rep Med ; 3(9): 100739, 2022 09 20.
Article in English | MEDLINE | ID: covidwho-2004612
ABSTRACT
Age is the strongest determinant of COVID-19 mortality, and over 2 billion people have received primary series vaccination with BNT162b2 (mRNA) or ChAdOx1 (adenoviral vector). However, the profile of sustained vaccine immunogenicity in older people is unknown. Here, we determine spike-specific humoral and cellular immunity to 8 months following BNT162b2 or ChAdOx1 in 245 people aged 80-98 years. Vaccines are strongly immunogenic, with antibodies retained in every donor, while titers fall to 23%-26% from peak. Peak immunity develops rapidly with standard interval BNT162b2, although antibody titers are enhanced 3.7-fold with extended interval. Neutralization of ancestral variants is superior following BNT162b2, while neutralization of Omicron is broadly negative. Conversely, cellular responses are stronger following ChAdOx1 and are retained to 33%-60% of peak with all vaccines. BNT162b2 and ChAdOx1 elicit strong, but differential, sustained immunogenicity in older people. These data provide a baseline to assess optimal booster regimen in this vulnerable age group.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Topics: Vaccines / Variants Limits: Aged / Humans Language: English Journal: Cell Rep Med Year: 2022 Document Type: Article Affiliation country: J.xcrm.2022.100739

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Topics: Vaccines / Variants Limits: Aged / Humans Language: English Journal: Cell Rep Med Year: 2022 Document Type: Article Affiliation country: J.xcrm.2022.100739