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Clinical Evaluation of Severe Acute Respiratory Syndrome Coronavirus 2 Rapid Antigen Tests During the Omicron Wave in South Africa.
Samsunder, Natasha; de Vos, Margaretha; Ngcapu, Sinaye; Giandhari, Jennifer; Lewis, Lara; Kharsany, Ayesha B M; Cawood, Cherie; de Oliveira, Tulio; Karim, Quarraisha Abdool; Karim, Salim Abdool; Naidoo, Kogieleum; Escadafal, Camille; Sivro, Aida.
  • Samsunder N; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.
  • de Vos M; FIND, the Global Alliance for Diagnostics, Geneva, Switzerland.
  • Ngcapu S; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.
  • Giandhari J; Department of Medical Microbiology, University of KwaZulu-Natal, Durban, South Africa.
  • Lewis L; KwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa.
  • Kharsany ABM; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.
  • Cawood C; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.
  • de Oliveira T; FIND, the Global Alliance for Diagnostics, Geneva, Switzerland.
  • Karim QA; Epicentre AIDS Risk Management, Durban, South Africa.
  • Karim SA; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.
  • Naidoo K; KwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa.
  • Escadafal C; Centre for Epidemic Response and Innovation, School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch, South Africa.
  • Sivro A; Department of Global Health, University of Washington, Seattle, USA.
J Infect Dis ; 226(8): 1412-1417, 2022 10 17.
Article in English | MEDLINE | ID: covidwho-2004993
ABSTRACT
We evaluated the performance of nasal and nasopharyngeal Standard Q COVID-19 [coronavirus disease 2019] Ag tests (SD Biosensor) and the Panbio COVID-19 Ag Rapid Test Device (nasal; Abbott) against the Abbott RealTime severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) assay during the Omicron (clades 21M, 21K, and 21L) wave in South Africa. Overall, all evaluated tests performed well, with high sensitivity (range, 77.78%-81.42%) and excellent specificity values (>99%). The sensitivity of rapid antigen tests increased above 90% in samples with cycle threshold <20, and all 3 tests performed best within the first week after symptom onset.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study Topics: Variants Limits: Humans Country/Region as subject: Africa Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study Topics: Variants Limits: Humans Country/Region as subject: Africa Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis