Rates of Medically Attended RSV Among US Adults: A Systematic Review and Meta-analysis.
Open Forum Infect Dis
; 9(7): ofac300, 2022 Jul.
Article
in English
| MEDLINE | ID: covidwho-2005006
ABSTRACT
Background:
Adult respiratory syncytial virus (RSV) vaccines are in the late stages of development. A comprehensive synthesis of adult RSV burden is needed to inform public health decision-making.Methods:
We performed a systematic review and meta-analysis of studies describing the incidence of medically attended RSV (MA-RSV) among US adults. We also identified studies reporting nasopharyngeal (NP) or nasal swab reverse transcription polymerase chain reaction (RT-PCR) results with paired serology (4-fold-rise) or sputum (RT-PCR) to calculate RSV detection ratios quantifying improved diagnostic yield after adding a second specimen type (ie, serology or sputum).Results:
We identified 14 studies with 15 unique MA-RSV incidence estimates, all based on NP or nasal swab RT-PCR testing alone. Pooled annual RSV-associated incidence per 100 000 adults ≥65 years of age was 178 (95% CI, 152â204; n = 8 estimates) hospitalizations (4 prospective studies 189; 4 model-based studies 157), 133 (95% CI, 0â319; n = 2) emergency department (ED) admissions, and 1519 (95% CI, 1109â1929; n = 3) outpatient visits. Based on 6 studies, RSV detection was â¼1.5 times higher when adding paired serology or sputum. After adjustment for this increased yield, annual RSV-associated rates per 100 000 adults age ≥65 years were 267 hospitalizations (uncertainty interval [UI], 228â306; prospective 282; model-based 236), 200 ED admissions (UI, 0â478), and 2278 outpatient visits (UI, 1663â2893). Persons <65 years with chronic medical conditions were 1.2-28 times more likely to be hospitalized for RSV depending on risk condition.Conclusions:
The true burden of RSV has been underestimated and is significant among older adults and individuals with chronic medical conditions. A highly effective adult RSV vaccine would have substantial public health impact.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Cohort study
/
Diagnostic study
/
Observational study
/
Prognostic study
/
Reviews
/
Systematic review/Meta Analysis
Topics:
Vaccines
Language:
English
Journal:
Open Forum Infect Dis
Year:
2022
Document Type:
Article
Affiliation country:
Ofid
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