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Inhaled corticosteroids do not affect the antibody titer against the SARS-CoV-2 spike protein in BNT162b2 mRNA vaccinated patients.
Nakajima, Takeo; Nagano, Tatsuya; Miyata, Yoshiharu; Murakami, Shoko; Mitsuyuki, Satoshi; Funakoshi, Yohei; Yakushijin, Kimikazu; Horimoto, Hitoshi; Nishimura, Yoshihiro; Kobayashi, Kazuyuki.
  • Nakajima T; Nakajima Medical Clinic, 1-8-3 Mikagenakamachi, Higashinada-ku, Kobe, 658-0054, Japan.
  • Nagano T; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan. tnagano@med.kobe-u.ac.jp.
  • Miyata Y; Division of Bioresource Research and Development, Department of Social/Community Medicine and Health Science, Kobe University Graduate School of Medicine, 1-5-1 Minatojimanakamachi, Chuo-ku, Kobe, 650-0047, Japan.
  • Murakami S; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
  • Mitsuyuki S; Department of Hematology, Kobe City Medical Center General Hospital, 2-1-1, Minatojimaminamimachi, Chuo-ku, Kobe, 650-0047, Japan.
  • Funakoshi Y; Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
  • Yakushijin K; Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
  • Horimoto H; Horimoto Clinic, 4-4-23, Okamoto, Higashinada-ku, Kobe, 658-0072, Japan.
  • Nishimura Y; Department of Respiratory Medicine, Kitaharima Medical Center, 926-250 Ichiba-cho, Ono, Hyogo, 675-1392, Japan.
  • Kobayashi K; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Allergy Asthma Clin Immunol ; 18(1): 78, 2022 Aug 25.
Article in English | MEDLINE | ID: covidwho-2005613
ABSTRACT

OBJECTIVES:

Oral corticosteroids reduce the antibody titer of the BNT162b2 mRNA vaccine against SARS-CoV-2. To date, the effect of inhaled corticosteroids on antibody titers is unknown. STUDY

DESIGN:

The design of this study is retrospective study.

METHODS:

We analyzed the relationship between the clinical features and total antibody titers against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein in 320 subjects who had never been infected with Coronavirus disease 2019 (COVID-19) and were vaccinated the second time with the BNT162b2 mRNA vaccine between October 1 to December 28, 2021.

RESULTS:

Of the 320 subjects, 205 were treated with inhaled corticosteroids. The median antibody titer of patients treated with inhaled corticosteroids was 572 U/mL, which was significantly higher than that of patients treated without inhaled corticosteroids (454U/mL, P = 0.00258). The median antibody titers of smokers, men, and patients aged 65 years and over, were 315.5 U/mL, 385 U/mL, and 425.5 U/mL, respectively. These results are significantly lower than those of patients who never smoked, women, and patients aged less than 64 years (582 U/mL [P < 0.0001], 682.5 U/mL [P < 0.0001], and 717 U/mL [P < 0.0001], respectively). The multivariate analysis revealed that females and age were independent antibody titer-reducing factors (P = 0.0001 and P < 0.0001, respectively).

CONCLUSIONS:

The use of inhaled corticosteroids did not reduce the antibody titer against SARS-CoV-2 spike protein. Clinicians should continue treatment with inhaled corticosteroids if indicated.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Topics: Vaccines Language: English Journal: Allergy Asthma Clin Immunol Year: 2022 Document Type: Article Affiliation country: S13223-022-00719-6

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Topics: Vaccines Language: English Journal: Allergy Asthma Clin Immunol Year: 2022 Document Type: Article Affiliation country: S13223-022-00719-6