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Historical Evolutionary Dynamics and Phylogeography Analysis of Transmissible Gastroenteritis Virus and Porcine Deltacoronavirus: Findings from 59 Suspected Swine Viral Samples from China.
Yan, Quanhui; Wu, Keke; Zeng, Weijun; Yu, Shu; Li, Yuwan; Sun, Yawei; Liu, Xiaodi; Ruan, Yang; Huang, Juncong; Ding, Hongxing; Yi, Lin; Zhao, Mingqiu; Chen, Jinding; Fan, Shuangqi.
  • Yan Q; College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
  • Wu K; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China.
  • Zeng W; Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, Guangzhou 510642, China.
  • Yu S; College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
  • Li Y; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China.
  • Sun Y; Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, Guangzhou 510642, China.
  • Liu X; College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
  • Ruan Y; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China.
  • Huang J; Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, Guangzhou 510642, China.
  • Ding H; College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
  • Yi L; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China.
  • Zhao M; Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, Guangzhou 510642, China.
  • Chen J; College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
  • Fan S; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China.
Int J Mol Sci ; 23(17)2022 Aug 29.
Article in English | MEDLINE | ID: covidwho-2006045
ABSTRACT
Since the beginning of the 21st century, humans have experienced three coronavirus pandemics, all of which were transmitted to humans via animals. Recent studies have found that porcine deltacoronavirus (PDCoV) can infect humans, so swine enteric coronavirus (SeCoV) may cause harm through cross-species transmission. Transmissible gastroenteritis virus (TGEV) and PDCoV have caused tremendous damage and loss to the pig industry around the world. Therefore, we analyzed the genome sequence data of these two SeCoVs by evolutionary dynamics and phylogeography, revealing the genetic diversity and spatiotemporal distribution characteristics. Maximum likelihood and Bayesian inference analysis showed that TGEV could be divided into two different genotypes, and PDCoV could be divided into four main lineages. Based on the analysis results inferred by phylogeography, we inferred that TGEV might originate from America, PDCoV might originate from Asia, and different migration events had different migration rates. In addition, we also identified positive selection sites of spike protein in TGEV and PDCoV, indicating that the above sites play an essential role in promoting membrane fusion to achieve adaptive evolution. In a word, TGEV and PDCoV are the past and future of SeCoV, and the relatively smooth transmission rate of TGEV and the increasing transmission events of PDCoV are their respective transmission characteristics. Our results provide new insights into the evolutionary characteristics and transmission diversity of these SeCoVs, highlighting the potential for cross-species transmission of SeCoV and the importance of enhanced surveillance and biosecurity measures for SeCoV in the context of the COVID-19 epidemic.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Swine Diseases / Transmissible gastroenteritis virus / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials Limits: Animals / Humans Language: English Year: 2022 Document Type: Article Affiliation country: Ijms23179786

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Swine Diseases / Transmissible gastroenteritis virus / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials Limits: Animals / Humans Language: English Year: 2022 Document Type: Article Affiliation country: Ijms23179786