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Unexpected Vertical Transmission of SARS-CoV-2: Discordant Clinical Course and Transmission from Mother to Newborn.
Boncompagni, Alessandra; De Agostini, Mattia; Lugli, Licia; Ternelli, Giliana; Colonna, Valeria; Biagioni, Emanuela; Bonasoni, Maria Paola; Salviato, Tiziana; Gabrielli, Liliana; Falconi, Mirella; Facchinetti, Fabio; Berardi, Alberto.
  • Boncompagni A; Neonatal Intensive Care Unit, Department of Medical and Surgical Sciences of Mothers, Children and Adults, University Hospital of Modena, 41124 Modena, Italy.
  • De Agostini M; Pediatric Unit, Department of Medical and Surgical Sciences of Mothers, Children and Adults, Post-Graduate School of Pediatrics, University of Modena and Reggio Emilia, 41124 Modena, Italy.
  • Lugli L; Neonatal Intensive Care Unit, Department of Medical and Surgical Sciences of Mothers, Children and Adults, University Hospital of Modena, 41124 Modena, Italy.
  • Ternelli G; Obstetrics and Gynecology Unit, Department of Medical and Surgical Sciences of Mothers, Children and Adults, University Hospital of Modena, 41124 Modena, Italy.
  • Colonna V; Obstetrics and Gynecology Unit, Department of Medical and Surgical Sciences of Mothers, Children and Adults, University Hospital of Modena, 41124 Modena, Italy.
  • Biagioni E; Intensive Care Unit, University Hospital of Modena, 41125 Modena, Italy.
  • Bonasoni MP; Pathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy.
  • Salviato T; Pathology Institute, University of Modena and Reggio Emilia, 41121 Modena, Italy.
  • Gabrielli L; Microbiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40126 Bologna, Italy.
  • Falconi M; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, Italy.
  • Facchinetti F; Obstetrics and Gynecology Unit, Department of Medical and Surgical Sciences of Mothers, Children and Adults, University Hospital of Modena, 41124 Modena, Italy.
  • Berardi A; Neonatal Intensive Care Unit, Department of Medical and Surgical Sciences of Mothers, Children and Adults, University Hospital of Modena, 41124 Modena, Italy.
Microorganisms ; 10(9)2022 Aug 26.
Article in English | MEDLINE | ID: covidwho-2006136
ABSTRACT
Mother-to-newborn COVID-19 transmission is mainly postnatal, but single-case reports and small case series have also described SARS-CoV-2 transplacental transmission. Unfortunately, studies regarding vertical transmission of SARS-CoV-2 lack systematic approaches to diagnosis and classification. So far, scientific evidence seems to suggest that the severity of maternal infection increases the risk of vertical transmission. We report two neonates born from COVID-19-positive mothers, of which one of the newborns had a vertical infection. The placental involvement, and consequent intrauterine transmission of SARS-CoV-2, were inversely related to the severity of the maternal disease. The description of cases divergent from current evidence on this topic could provide new insights to better understand SARS-CoV-2 vertical transmission.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Prognostic study / Systematic review/Meta Analysis Language: English Year: 2022 Document Type: Article Affiliation country: Microorganisms10091718

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Prognostic study / Systematic review/Meta Analysis Language: English Year: 2022 Document Type: Article Affiliation country: Microorganisms10091718