Reliability of the In Silico Prediction Approach to In Vitro Evaluation of Bacterial Toxicity.
Sensors (Basel)
; 22(17)2022 Aug 31.
Article
in English
| MEDLINE | ID: covidwho-2006171
ABSTRACT
Several pathogens that spread through the air are highly contagious, and related infectious diseases are more easily transmitted through airborne transmission under indoor conditions, as observed during the COVID-19 pandemic. Indoor air contaminated by microorganisms, including viruses, bacteria, and fungi, or by derived pathogenic substances, can endanger human health. Thus, identifying and analyzing the potential pathogens residing in the air are crucial to preventing disease and maintaining indoor air quality. Here, we applied deep learning technology to analyze and predict the toxicity of bacteria in indoor air. We trained the ProtBert model on toxic bacterial and virulence factor proteins and applied them to predict the potential toxicity of some bacterial species by analyzing their protein sequences. The results reflect the results of the in vitro analysis of their toxicity in human cells. The in silico-based simulation and the obtained results demonstrated that it is plausible to find possible toxic sequences in unknown protein sequences.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Air Pollution, Indoor
/
COVID-19
Type of study:
Experimental Studies
/
Prognostic study
Limits:
Humans
Language:
English
Year:
2022
Document Type:
Article
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