High Flow Nasal Oxygen (HFNO) vs Non-invasive Ventilation (NIV) for Acute Hypoxemic Respiratory Failure (AHRF) in COVID-19
Indian Journal of Critical Care Medicine
; 26:S72, 2022.
Article
in English
| EMBASE | ID: covidwho-2006361
ABSTRACT
Background:
COVID-19 patients who develop hypoxemic respiratory failure despite conventional oxygen therapy usually require high flow nasal oxygen (HFNO) or non-invasive ventilation (NIV).Aim:
To compare the effect of both in managing COVID- 19 induced respiratory failure and to determine whether HFNO decreases the rate of intubation when compared with NIV. Settings anddesign:
Single centre, retrospective observational study. Materials andmethods:
Data collected from medical records. As per the inclusion criteria, patients who received either HFNO or NIV as initial therapy for at least 2 calendar days were analysed. Both the therapies were compared in around 200 patients (HFNO = 100, NIV = 100), with the rate of intubation at day 14 as the primary outcome and length of ICU stay, hospital stay, mortality at day 28, no. of ventilatory free days, complications during ICU stay and comfort score as secondary outcomes. Statisticalanalysis:
Data analysis was done using SPSS software. p value < 0.05 was considered statistically significant.Results:
The rate of intubation and mortality rates were higher in the NIV group (P = 0.001), whereas there was no difference in length of hospital or ICU stay among the both (P = 0.15, 0.75, respectively). HFNO group patients were more comfortable (P < 0.05).Conclusion:
HFNO is effective in the management of COVID- 19 induced acute hypoxemic respiratory failure with a lower rate of intubation, lower mortality rate, and better tolerance compared to NIV though it does not reduce the duration of ICU or hospital stay.
oxygen; acute hypoxemic respiratory failure; adult; artificial ventilation; comfort; complication; conference abstract; controlled study; coronavirus disease 2019; data analysis software; drug therapy; female; hospitalization; human; intubation; length of stay; major clinical study; male; medical record; mortality; mortality rate; noninvasive ventilation; observational study; outcome assessment; respiratory failure; retrospective study
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Indian Journal of Critical Care Medicine
Year:
2022
Document Type:
Article
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