To Identify Rising Level of CRP and d-Dimer As Predictor of Increased Morbidity and Mortality in Covid-19 Patient. A Retrospective Observational Study

ABSTRACT

Aim and background: Cytokine storm caused by the release of proinflammatory mediators, e.g., IL-6, TNF-, IL2, IL10, G-CSF, etc., is the hallmark of COVID-19 disease. This cytokine storm is characterized by immuno-thrombomodulation. C-Reactive Protein (CRP) and d-dimer are markers of proinflammatory state, which can also be used as a prognostic marker for the underlying disease processes. Objective: To determine the clinical utility of raised C-reactive protein (CRP) and d-Dimer levels as prognostic markers in patients with the diagnosis of COVID-19. Materials and methods: This retrospective observational study will be conducted at Max Super speciality Hospital I.P. Extension, Delhi after ethical committee clearance. Adult (age > 18 years) patients with confirmed diagnosis of COVID-19 admitted to COVID-ICU between 1st April 2021 till 30th June 2021 will be included and checked for CRP and d-Dimer values retrospectively. Correlation between raised CRP and d-dimer on presentation and rising trend of markers with 28-day mortality, Average length of ICU stay, need for invasive mechanical ventilation, and need for Renal Replacement Therapy will be seen. Results: Results will be shared after the completion of the study.