Reactivation of latent tuberculosis post SARS-CoV-2 infection
Medical Journal of Malaysia
; 77:32, 2022.
Article
in English
| EMBASE | ID: covidwho-2006924
ABSTRACT
Introduction:
Tuberculosis (TB) is an airborne infectious disease caused by the Mycobacterium tuberculosis (MTB) complex. It attacks the lungs and other extra-pulmonary sites. It remains a major public health concern in Malaysia with incidence of 79/100,000 in 2015. Case Description We report a case of a 29-year-old lady, presented with a complain of generalised abdominal pain for 2 months. Patient had Covid-19 infection in pregnancy 8 months ago and underwent lower segment caesarean section at term for fetal distress. In 2018 she had TB screening for contact tracing which turned out to be negative. In this current presentation, a Computerized-Tomography (CT) Abdomen-Pelvis scan reported a left ovarian lesion with pseudomyxoma peritonei and omental caking. Diagnostic laparoscopy showed dense adhesions between peritoneal wall and surrounding organs with multiple pockets and fluid collections seen. Whitish friable lesion seen over the peritoneum. Samples sent for histopathology, culture and sensitivity and MTB PCR. Histopathology sample returned as caseating granuloma;suggestive of extrapulmonary tuberculosis. Microscopically, acid fast bacilli seen in Ziehl-Neelsen staining. Peritoneal fluid was transudative in nature. The diagnosis of peritoneal tuberculosis was established, and patient was referred to Infectious Disease team for treatment of active TB.Discussion:
Reactivation of latent TB may be explained by immune-suppressive state associated with Covid-19 may be implicated in the progression of latent to active TB in a similar manner to HIV. Very few cases post Covid-19 activation of latent TB have been reported. This is one such a case.
abdominal pain; adult; Bacilli; cancer patient; case report; caseating granuloma; cesarean section; clinical article; communicable disease; complication; computer assisted tomography; conference abstract; contact examination; coronavirus disease 2019; extrapulmonary tuberculosis; female; fetus distress; histopathology; human; Human immunodeficiency virus; human tissue; laparoscopy; latent tuberculosis; Mycobacterium tuberculosis; nonhuman; omentum; peritoneal fluid; peritoneum pseudomyxoma; pregnancy complication; tuberculosis; tuberculous peritonitis
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Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Medical Journal of Malaysia
Year:
2022
Document Type:
Article
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