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Postvaccinal GABA-B receptor antibody encephalitis after ChAdOx1 nCoV-19 vaccination.
Ahn, Seon-Jae; Lee, Soon-Tae; Chu, Kon.
  • Ahn SJ; Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
  • Lee ST; Hospital Medicine Center, Seoul National University Hospital, Seoul, South Korea.
  • Chu K; Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Ann Clin Transl Neurol ; 9(10): 1673-1678, 2022 10.
Article in English | MEDLINE | ID: covidwho-2007086
ABSTRACT
Several cases of autoimmune encephalitis have been reported after ChAdOx1 nCoV-19 (AZD1222) vaccination. We encountered a male patient who presented with generalized tonic-clonic seizures, cognitive decline, and gait disturbance that occurred suddenly after the second dose of the ChAdOx1 nCoV-19 vaccine. Clinical presentation and magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) test results were compatible with limbic encephalitis. Synaptic autoantibody tests confirmed serum and CSF GABA B receptor antibodies were present. The patient was treated with immunotherapy with intravenous immunoglobulin and rituximab. This GABA-B receptor antibody encephalitis case occurred presumably due to transient autoantibody production following vaccine administration.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Encephalitis / COVID-19 / ChAdOx1 nCoV-19 Type of study: Case report / Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Humans / Male Language: English Journal: Ann Clin Transl Neurol Year: 2022 Document Type: Article Affiliation country: Acn3.51659

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Encephalitis / COVID-19 / ChAdOx1 nCoV-19 Type of study: Case report / Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Humans / Male Language: English Journal: Ann Clin Transl Neurol Year: 2022 Document Type: Article Affiliation country: Acn3.51659