Postvaccinal GABA-B receptor antibody encephalitis after ChAdOx1 nCoV-19 vaccination.
Ann Clin Transl Neurol
; 9(10): 1673-1678, 2022 10.
Article
in English
| MEDLINE | ID: covidwho-2007086
ABSTRACT
Several cases of autoimmune encephalitis have been reported after ChAdOx1 nCoV-19 (AZD1222) vaccination. We encountered a male patient who presented with generalized tonic-clonic seizures, cognitive decline, and gait disturbance that occurred suddenly after the second dose of the ChAdOx1 nCoV-19 vaccine. Clinical presentation and magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) test results were compatible with limbic encephalitis. Synaptic autoantibody tests confirmed serum and CSF GABA B receptor antibodies were present. The patient was treated with immunotherapy with intravenous immunoglobulin and rituximab. This GABA-B receptor antibody encephalitis case occurred presumably due to transient autoantibody production following vaccine administration.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Encephalitis
/
COVID-19
/
ChAdOx1 nCoV-19
Type of study:
Case report
/
Observational study
/
Prognostic study
Topics:
Long Covid
/
Vaccines
Limits:
Humans
/
Male
Language:
English
Journal:
Ann Clin Transl Neurol
Year:
2022
Document Type:
Article
Affiliation country:
Acn3.51659
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