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[Fecal microbiota transplantation: indications, risks and opportunities]. / Fäkaler Mikrobiomtransfer ­ Indikationen, Risiken und Chancen.
Stallmach, Andreas; Steube, Arndt; Stallhofer, Johannes; Grunert, Philip C; Merkel, Ute; Hartmann, Michael.
  • Stallmach A; Klinik für Innere Medizin IV (Gastroenterologie, Hepatologie, Infektiologie), Universitätsklinikum Jena, Am Klinikum 1, 07743, Jena, Deutschland. andreas.stallmach@med.uni-jena.de.
  • Steube A; Klinik für Innere Medizin IV (Gastroenterologie, Hepatologie, Infektiologie), Universitätsklinikum Jena, Am Klinikum 1, 07743, Jena, Deutschland.
  • Stallhofer J; Klinik für Innere Medizin IV (Gastroenterologie, Hepatologie, Infektiologie), Universitätsklinikum Jena, Am Klinikum 1, 07743, Jena, Deutschland.
  • Grunert PC; Klinik für Innere Medizin IV (Gastroenterologie, Hepatologie, Infektiologie), Universitätsklinikum Jena, Am Klinikum 1, 07743, Jena, Deutschland.
  • Merkel U; Apotheke des Universitätsklinikums Jena, Jena, Deutschland.
  • Hartmann M; Apotheke des Universitätsklinikums Jena, Jena, Deutschland.
Inn Med (Heidelb) ; 63(10): 1036-1042, 2022 Oct.
Article in German | MEDLINE | ID: covidwho-2007121
ABSTRACT
Fecal microbiome transfer (FMT) involving the transfer of the microbiome of healthy stool donors to patients with various diseases has been performed in Germany in clinical studies and individual treatment attempts. There is no doubt that FMT is an effective therapeutic principle for recurrent Clostridium difficile infection and ulcerative colitis. From a medico-legal point of view, it should be stressed that, in Germany, the microbiome to be transferred is regarded as a drug, the manufacture of which is subject to the Medicines Act and the risk information from the Federal Institute for Drugs and Medical Devices. The background of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and the potential risk of transmitting pathogens must also be considered. There is an obligation to notify the competent state authorities to perform FMTs in the context of individual treatment attempts. In the context of the limited availability and the fundamental problem of infection, future studies aim to identify the therapeutically active components in the microbiome. Recombinant production is the aim. Initial results represent preliminary steps, as these concepts are not yet established in clinical practice.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Clostridioides difficile / Clostridium Infections / COVID-19 Type of study: Prognostic study Limits: Humans Language: German Journal: Inn Med (Heidelb) Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Clostridioides difficile / Clostridium Infections / COVID-19 Type of study: Prognostic study Limits: Humans Language: German Journal: Inn Med (Heidelb) Year: 2022 Document Type: Article