CRISPR-Cas system: from diagnostic tool to potential antiviral treatment.
Appl Microbiol Biotechnol
; 106(18): 5863-5877, 2022 Sep.
Article
in English
| MEDLINE | ID: covidwho-2007131
ABSTRACT
This mini review focuses on the diagnosis and treatment of virus diseases using Crisper-Cas technology. The present paper describes various strategies involved in diagnosing diseases using Crispr-Cas-based assays. Additionally, CRISPR-Cas systems offer great potential as new therapeutic tools for treating viral infections including HIV, Influenza, and SARS-CoV-2. There are several major challenges to be overcome before this technology can be applied routinely in clinical settings, such as finding a suitable delivery tool, toxicity, and immunogenicity, as well as off-target effects. This review also discusses ways to deal with the challenges associated with Crisper-Cas technology. KEY POINTS ⢠Crisper technology is being applied to diagnose infectious and non-infectious diseases. ⢠A new generation of CRISPR-Cas-based assays has been developed which detect pathogens within minutes, providing rapid diagnosis of diseases. ⢠Crispr-Cas tools can be used to combat viral infections, specifically HIV, influenza, and SARS-CoV-2.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Virus Diseases
/
HIV Infections
/
Influenza, Human
/
COVID-19
/
COVID-19 Drug Treatment
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Appl Microbiol Biotechnol
Year:
2022
Document Type:
Article
Affiliation country:
S00253-022-12135-2
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