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Multisystem inflammatory syndrome in children: clinical presentation, management, and short- and long-term outcomes.
Sezer, Müge; Çelikel, Elif; Tekin, Zahide Ekici; Aydin, Fatma; Kurt, Tuba; Tekgöz, Nilüfer; Karagöl, Cüneyt; Coskun, Serkan; Kaplan, Melike Mehves; Öner, Nimet; Polat, Merve Cansu; Gül, Ayse Esin Kibar; Parlakay, Aslinur Özkaya; Acar, Banu.
  • Sezer M; Department of Pediatric Rheumatology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey. muge2202@hotmail.com.
  • Çelikel E; Department of Pediatric Rheumatology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
  • Tekin ZE; Department of Pediatric Rheumatology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
  • Aydin F; Department of Pediatric Rheumatology, Faculty of Medicine, Ankara University, Ankara, Turkey.
  • Kurt T; Department of Pediatric Rheumatology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
  • Tekgöz N; Department of Pediatric Rheumatology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
  • Karagöl C; Department of Pediatric Rheumatology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
  • Coskun S; Department of Pediatric Rheumatology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
  • Kaplan MM; Department of Pediatric Rheumatology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
  • Öner N; Department of Pediatric Rheumatology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
  • Polat MC; Department of Pediatric Rheumatology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
  • Gül AEK; Department of Pediatric Cardiology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
  • Parlakay AÖ; Department of Pediatric Infectious Disease, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
  • Acar B; Department of Pediatric Rheumatology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
Clin Rheumatol ; 41(12): 3807-3816, 2022 Dec.
Article in English | MEDLINE | ID: covidwho-2007160
ABSTRACT

OBJECTIVE:

In this study, it was aimed to evaluate the demographic, clinical and laboratory characteristics of MIS-C patients in our hospital, to share our treatment approach, and to assess the outcomes of short- and long-term follow-up.

METHODS:

MIS-C patients who were admitted and treated in our hospital between July 2020 and July 2021 were evaluated. Demographic, clinical, laboratory, and follow-up data were collected from patient records retrospectively.

RESULTS:

A total of 123 patients with MIS-C (median age, 9.6 years) were included the study. Nineteen (15.4%) were mild, 56 (45.6%) were moderate, and 48 (39%) were severe MIS-C. High CRP, ferritin, pro-BNP, troponin, IL-6, and D-dimer values were found in proportion to the severity of the disease (p < 0.001, p < 0.001, p < 0.001, p < 0.001, p = 0.005, p < 0.001), respectively. Two (1.6%) patients died. The mean follow-up period was 7.8 months. Valve failure, left ventricular dysfunction/hypertrophy, coronary involvement, and pericardial effusion were the most common cardiac pathologies in the short- and long-term follow-up of the patients. In the long-term follow-up, the most common reasons for admission to the hospital were recurrent abdominal pain (14.2%), cardiac findings (14.2%), pulmonary symptoms (8%), fever (7.1%), neuropsychiatric findings (6.2%) and hypertension (3.5%). Neuropsychiatric abnormalities were observed significantly more common in severe MIS-C patients at follow-up (p = 0.016). In the follow-up, 6.2% of the patients required recurrent hospitalization.

CONCLUSION:

MIS-C is a serious and life-threatening disease, according to short-term outcomes. In addition to the cardiac findings of patients with MIS-C, long-term outcomes such as neuropsychiatric findings, persistent gastrointestinal symptoms, fever and pulmonary symptoms should be monitored. Key Points • In MIS-C patients, attention should be paid not only to cardiac findings, but also to symptoms related to other systems. • Patients should be followed up in terms of neuropsychiatric findings, persistent gastrointestinal symptoms, fever and pulmonary symptoms that may occur during follow-up.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Connective Tissue Diseases / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Child / Humans Language: English Journal: Clin Rheumatol Year: 2022 Document Type: Article Affiliation country: S10067-022-06350-5

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Connective Tissue Diseases / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Child / Humans Language: English Journal: Clin Rheumatol Year: 2022 Document Type: Article Affiliation country: S10067-022-06350-5