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Molecular characterization and sequecing analysis of SARS-CoV-2 genome in Minas Gerais, Brazil.
Ferreira, Giulia Magalhães; Claro, Ingra Morales; Grosche, Victória Riquena; Cândido, Darlan; José, Diego Pandeló; Rocha, Esmenia Coelho; de Moura Coletti, Thaís; Manuli, Erika Regina; Gaburo, Nelson; Faria, Nuno Rodrigues; Sabino, Ester Cerdeira; de Jesus, Jaqueline Goes; Jardim, Ana Carolina Gomes.
  • Ferreira GM; Institute of Biomedical Science, Federal University of Uberlândia, Uberlândia, MG, Brazil.
  • Claro IM; Institute of Tropical Medicine, University of São Paulo Medical School, São Paulo, Brazil; Department of Infectious and Parasitic Diseases, University of São Paulo Medical School, São Paulo, Brazil.
  • Grosche VR; Institute of Biomedical Science, Federal University of Uberlândia, Uberlândia, MG, Brazil; Institute of Bioscience, Humanities and Exact Sciences, São Paulo State University, São José do Rio Preto, São Paulo, Brazil.
  • Cândido D; Institute of Tropical Medicine, University of São Paulo Medical School, São Paulo, Brazil; Department of Zoology, University of Oxford, Oxford, UK.
  • José DP; Federal University of Triângulo Mineiro, Iturama, MG, Brazil.
  • Rocha EC; Institute of Tropical Medicine, University of São Paulo Medical School, São Paulo, Brazil; Department of Infectious and Parasitic Diseases, University of São Paulo Medical School, São Paulo, Brazil.
  • de Moura Coletti T; Institute of Tropical Medicine, University of São Paulo Medical School, São Paulo, Brazil; Department of Infectious and Parasitic Diseases, University of São Paulo Medical School, São Paulo, Brazil.
  • Manuli ER; Institute of Tropical Medicine, University of São Paulo Medical School, São Paulo, Brazil; Department of Infectious and Parasitic Diseases, University of São Paulo Medical School, São Paulo, Brazil.
  • Gaburo N; DB, Diagnósticos do Brasil, São Paulo, Brazil.
  • Faria NR; Institute of Tropical Medicine, University of São Paulo Medical School, São Paulo, Brazil; Department of Zoology, University of Oxford, Oxford, UK; MCR Centre for Global Infectious Disease Analysis, J-IDEA, Imperial College London, London, UK.
  • Sabino EC; Institute of Tropical Medicine, University of São Paulo Medical School, São Paulo, Brazil; Department of Infectious and Parasitic Diseases, University of São Paulo Medical School, São Paulo, Brazil.
  • de Jesus JG; Institute of Tropical Medicine, University of São Paulo Medical School, São Paulo, Brazil; Department of Infectious and Parasitic Diseases, University of São Paulo Medical School, São Paulo, Brazil.
  • Jardim ACG; Institute of Biomedical Science, Federal University of Uberlândia, Uberlândia, MG, Brazil; Institute of Bioscience, Humanities and Exact Sciences, São Paulo State University, São José do Rio Preto, São Paulo, Brazil. Electronic address: jardim@ufu.br.
Biologicals ; 2022 Sep 02.
Article in English | MEDLINE | ID: covidwho-2007466
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first identified in Wuhan, China, is the causative agent of the coronavirus disease 2019 (COVID-19). Since its first notification in São Paulo state (SP) on 26th February 2020, more than 22,300,000 cases and 619,000 deaths were reported in Brazil. In early pandemic, SARS-CoV-2 spread locally, however, over time, this virus was disseminated to other regions of the country. Herein, we performed genomic sequencing and phylogenetic analysis of SARS-CoV-2 using 20 clinical samples of COVID-19 confirmed cases from 9 cities of Minas Gerais state (MG), in order to evaluate the molecular properties of circulating viral strains in this locality from March to May 2020. Our analyses demonstrated the circulation of B.1 lineage isolates in the investigated locations and nucleotide substitutions were observed into the genomic regions related to important viral structures. Additionally, sequences generated in this study clustered with isolates from SP, suggesting a dissemination route between these two states. Alternatively, monophyletic groups of sequences from MG and other states or country were observed, indicating independent events of virus introduction. These results reinforce the need of genomic surveillance for understand the ongoing spread of emerging viral pathogens.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Country/Region as subject: South America / Brazil Language: English Journal subject: Allergy and Immunology Year: 2022 Document Type: Article Affiliation country: J.biologicals.2022.08.001

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Country/Region as subject: South America / Brazil Language: English Journal subject: Allergy and Immunology Year: 2022 Document Type: Article Affiliation country: J.biologicals.2022.08.001