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Antibody titers and neutralizing activity in cases of COVID-19 after a single dose of vaccination.
Okumura, Nobumasa; Saito, Sho; Takamatsu, Yuki; Takeuchi, Junko S; Asai, Yusuke; Sanada, Mio; Iwamoto, Noriko; Maeda, Kenji; Mitsuya, Hiroaki; Ohmagari, Norio.
  • Okumura N; Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.
  • Saito S; Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan. Electronic address: ssaito@hosp.ncgm.go.jp.
  • Takamatsu Y; Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.
  • Takeuchi JS; Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan.
  • Asai Y; AMR Clinical Reference Center, National Center for Global Health and Medicine, Tokyo, Japan.
  • Sanada M; Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.
  • Iwamoto N; Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.
  • Maeda K; Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.
  • Mitsuya H; Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.
  • Ohmagari N; Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan; AMR Clinical Reference Center, National Center for Global Health and Medicine, Tokyo, Japan.
J Infect Chemother ; 28(12): 1704-1706, 2022 Dec.
Article in English | MEDLINE | ID: covidwho-2007850
ABSTRACT
Vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have shown high efficacy in preventing the onset of disease. However, the immune response to infection immediately after the first vaccination remains unknown. We examined the anti-SARS-CoV-2-binding-antibody titers and neutralizing activity in patients who developed coronavirus disease 2019 after the first vaccination. The amount of anti-SARS-CoV-2-binding antibodies and neutralizing activity drastically increased from the first to the second collection. Our results may provide important data on the course of immune response following vaccination.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: J Infect Chemother Journal subject: Microbiology / Drug Therapy Year: 2022 Document Type: Article Affiliation country: J.jiac.2022.08.026

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: J Infect Chemother Journal subject: Microbiology / Drug Therapy Year: 2022 Document Type: Article Affiliation country: J.jiac.2022.08.026