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A prospective study of risk factors associated with seroprevalence of SARS-CoV-2 antibodies in healthcare workers at a large UK teaching hospital.
Cooper, Daniel J; Lear, Sara; Watson, Laura; Shaw, Ashley; Ferris, Mark; Doffinger, Rainer; Bousfield, Rachel; Sharrocks, Katherine; Weekes, Michael P; Warne, Ben; Sparkes, Dominic; Jones, Nick K; Rivett, Lucy; Routledge, Matthew; Chaudhry, Afzal; Dempsey, Katherine; Matson, Montgomery; Lakha, Adil; Gathercole, George; O'Connor, Olivia; Wilson, Emily; Shahzad, Orthi; Toms, Kieran; Thompson, Rachel; Halsall, Ian; Halsall, David; Houghton, Sally; Papadia, Sofia; Kingston, Nathalie; Stirrups, Kathleen E; Graves, Barbara; Townsend, Paul; Walker, Neil; Stark, Hannah; De Angelis, Daniela; Seaman, Shaun; Dougan, Gordon; Bradley, John R; Török, M Estée; Goodfellow, Ian; Baker, Stephen.
  • Cooper DJ; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Global and Tropical Health Division, Menzies School of Heath Research and Charles Darwin University, Darwin, Northern Territory, Australia; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biome
  • Lear S; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • Watson L; NIHR Cambridge Clinical Research Facility.
  • Shaw A; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • Ferris M; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • Doffinger R; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • Bousfield R; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • Sharrocks K; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • Weekes MP; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • Warne B; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • Sparkes D; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Clinical Microbiology and Public Health Laboratory, Public Health England, United Kingdom.
  • Jones NK; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Clinical Microbiology and Public Health Laboratory, Public Health England, United Kingdom.
  • Rivett L; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Clinical Microbiology and Public Health Laboratory, Public Health England, United Kingdom.
  • Routledge M; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Clinical Microbiology and Public Health Laboratory, Public Health England, United Kingdom.
  • Chaudhry A; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • Dempsey K; NIHR Cambridge Clinical Research Facility.
  • Matson M; University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • Lakha A; University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • Gathercole G; University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • O'Connor O; University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • Wilson E; University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • Shahzad O; University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • Toms K; University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • Thompson R; University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • Halsall I; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • Halsall D; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • Houghton S; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • Papadia S; NIHR BioResource, NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK; Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
  • Kingston N; NIHR BioResource, NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK; Department of Haematology, School of Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
  • Stirrups KE; NIHR BioResource, NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK; Department of Haematology, School of Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
  • Graves B; NIHR BioResource, NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK; Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
  • Townsend P; NIHR BioResource, NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK.
  • Walker N; NIHR BioResource, NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK; Department of Haematology, School of Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
  • Stark H; NIHR BioResource, NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK; Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
  • De Angelis D; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.
  • Seaman S; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.
  • Dougan G; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK.
  • Bradley JR; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; NIHR BioResource, NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK.
  • Török ME; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK.
  • Goodfellow I; Department of pathology, Division of virology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
  • Baker S; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK.
J Infect ; 85(5): 557-564, 2022 11.
Article in English | MEDLINE | ID: covidwho-2007856
ABSTRACT

OBJECTIVES:

To describe the risk factors for SARS-CoV-2 infection in UK healthcare workers (HCWs).

METHODS:

We conducted a prospective sero-epidemiological study of HCWs at a major UK teaching hospital using a SARS-CoV-2 immunoassay. Risk factors for seropositivity were analysed using multivariate logistic regression.

RESULTS:

410/5,698 (7·2%) staff tested positive for SARS-CoV-2 antibodies. Seroprevalence was higher in those working in designated COVID-19 areas compared with other areas (9·47% versus 6·16%) Healthcare assistants (aOR 2·06 [95%CI 1·14-3·71]; p=0·016) and domestic and portering staff (aOR 3·45 [95% CI 1·07-11·42]; p=0·039) had significantly higher seroprevalence than other staff groups after adjusting for age, sex, ethnicity and COVID-19 working location. Staff working in acute medicine and medical sub-specialities were also at higher risk (aOR 2·07 [95% CI 1·31-3·25]; p<0·002). Staff from Black, Asian and minority ethnic (BAME) backgrounds had an aOR of 1·65 (95% CI 1·32 - 2·07; p<0·001) compared to white staff; this increased risk was independent of COVID-19 area working. The only symptoms significantly associated with seropositivity in a multivariable model were loss of sense of taste or smell, fever, and myalgia; 31% of staff testing positive reported no prior symptoms.

CONCLUSIONS:

Risk of SARS-CoV-2 infection amongst HCWs is highly heterogeneous and influenced by COVID-19 working location, role, age and ethnicity. Increased risk amongst BAME staff cannot be accounted for solely by occupational factors.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Country/Region as subject: Europa Language: English Journal: J Infect Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Country/Region as subject: Europa Language: English Journal: J Infect Year: 2022 Document Type: Article