COVID-19 diverse outcomes: Aggravated reinfection, type I interferons and antibodies.
Med Hypotheses
; 167: 110943, 2022 Oct.
Article
in English
| MEDLINE | ID: covidwho-2007952
ABSTRACT
SARS-CoV-2 infection intrigued medicine with diverse outcomes ranging from asymptomatic to severe acute respiratory syndrome (SARS) and death. After more than two years of pandemic, reports of reinfection concern researchers and physicists. Here, we will discuss potential mechanisms that can explain reinfections, including the aggravated ones. The major topics of this hypothesis paper are the disbalance between interferon and antibodies responses, HLA heterogeneity among the affected population, and increased proportion of cytotoxic CD4+ T cells polarization in relation to T follicular cells (Tfh) subtypes. These features affect antibody levels and hamper the humoral immunity necessary to prevent or minimize the viral burden in the case of reinfections.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Language:
English
Journal:
Med Hypotheses
Year:
2022
Document Type:
Article
Affiliation country:
J.mehy.2022.110943
Similar
MEDLINE
...
LILACS
LIS