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Rapid diagnostic tests in the management of pneumonia.
Riccobono, Eleonora; Bussini, Linda; Giannella, Maddalena; Viale, Pierluigi; Rossolini, Gian Maria.
  • Riccobono E; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Bussini L; Department of Medical Biotechnologies, University of Siena, Siena, Italy.
  • Giannella M; Infectious Diseases Unit, Department of Medical and Surgical Sciences, Policlinico Sant' Orsola, Bologna, Italy.
  • Viale P; Infectious Diseases Unit, Department of Medical and Surgical Sciences, Policlinico Sant' Orsola, Bologna, Italy.
  • Rossolini GM; Infectious Diseases Unit, Department of Medical and Surgical Sciences, Policlinico Sant' Orsola, Bologna, Italy.
Expert Rev Mol Diagn ; 22(1): 49-60, 2022 Jan.
Article in English | MEDLINE | ID: covidwho-2008441
ABSTRACT

INTRODUCTION:

Pneumonia is one of the main causes of mortality associated with infectious diseases worldwide. Several challenges have been identified in the management of patients with pneumonia, ranging from accurate and cost-effective microbiological investigations, prompt and adequate therapeutic management, and optimal treatment duration. AREAS COVERED In this review, an updated summary on the current management of pneumonia patients is provided and the epidemiological issues of infectious respiratory diseases, which in the current pandemic situation are of particular concern, are addressed. The clinical and microbiological approaches to pneumonia diagnosis are reviewed, including discussion about the new molecular assays pointing out both their strengths and limitations. Finally, the current recommendations about antibiotic treatment are examined and discussed depending on the epidemiological contexts, including those with high prevalence of multidrug-resistant bacteria. EXPERT OPINION We claim that rapid diagnostic tests, if well-positioned in the diagnostic workflow and reserved for the subset of patients who could most benefit from these technologies, may represent an interesting and feasible tool to optimize timing of targeted treatments especially in terms of early de-escalation or discontinuation of antibiotic therapy.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / Diagnostic Tests, Routine Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Language: English Journal: Expert Rev Mol Diagn Journal subject: Molecular Biology Year: 2022 Document Type: Article Affiliation country: 14737159.2022.2018302

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / Diagnostic Tests, Routine Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Language: English Journal: Expert Rev Mol Diagn Journal subject: Molecular Biology Year: 2022 Document Type: Article Affiliation country: 14737159.2022.2018302