Anti-N-methyl-D-aspartate receptor encephalitis after coronavirus disease 2019: A case report and literature review.
Medicine (Baltimore)
; 101(35): e30464, 2022 Sep 02.
Article
in English
| MEDLINE | ID: covidwho-2008672
ABSTRACT
RATIONALE Coronavirus disease 2019 (COVID-19) has become a global pandemic and COVID-19-associated anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis may occur through an immune-mediated pathomechanism. PATIENT CONCERNS A 21-year-old woman with a history of COVID-19 presented to our hospital with memory decline and psychiatric symptoms. DIAGNOSIS The patient was diagnosed with anti-NMDAR encephalitis. INTERVENTION Intravenous methylprednisolone (1 g/day over 5 days) followed by immunoglobulin (0.4 g/kg/day over 5 days) were administered. The patient underwent laparoscopic salpingo-oophorectomy to remove an ovarian teratoma. OUTCOMES:
The patient was discharged with sequelae of short-term memory impairment, without other neuropsychiatric symptoms. LESSONS Cases of previously reported anti-NMDAR encephalitis with COVID-19 were reviewed and compared with the present case. Clinicians should be aware of the occurrence of anti-NMDAR encephalitis in patients who present with neuropsychiatric complaints during or after exposure to COVID-19. Further studies are required to determine the causal relationship between the 2 diseases and predict the prognosis of anti-NMDAR encephalitis after COVID-19 exposure.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Anti-N-Methyl-D-Aspartate Receptor Encephalitis
/
COVID-19
Type of study:
Case report
/
Diagnostic study
/
Prognostic study
/
Reviews
Topics:
Long Covid
Limits:
Adult
/
Female
/
Humans
/
Young adult
Language:
English
Journal:
Medicine (Baltimore)
Year:
2022
Document Type:
Article
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