PDSTP Is the First Drug in Class to Treat Coronavirus Infection.
Her Russ Acad Sci
; 92(4): 488-490, 2022.
Article
in English
| MEDLINE | ID: covidwho-2008786
ABSTRACT
The results of a comprehensive study are presented on the development and creation of an original small PDSTP molecule, able to prevent the SARS-CoV-2 coronavirus infection from binding to the host cell. The PDSTP molecule was designed to electrostatically interact with heparan sulfate proteoglycans on the cell surface, and coronaviruses, particularly SARS-CoV-2, use this mechanism as the first stage of interaction with the cell. By blocking this process, it is possible to stop the life cycle of the virus, thus leading to its death. The drug candidate PDSTP, with its unique mechanism of action, is characterized by a very low toxicity and a high safety profile and demonstrates good efficacy in animal experiments.
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Collection:
International databases
Database:
MEDLINE
Language:
English
Journal:
Her Russ Acad Sci
Year:
2022
Document Type:
Article
Affiliation country:
S1019331622040190
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