IMMUNOMODULATORY EFFECTS of SARS-COV-2 VACCINATION: INCREASE of REGULATORY T CELLS after MRNA VACCINE
Annals of the Rheumatic Diseases
; 81:1700, 2022.
Article
in English
| EMBASE | ID: covidwho-2009135
ABSTRACT
Background:
Besides the ability to induce antigen-specifc responses, vaccines can be endowed with immunomodulatory properties including the capacity to induce or downregulate regulatory T cells (Treg) that suppress adaptative and autoreactive immune responses (1).Objectives:
We asked if an anti-SARS-CoV-2 mRNA vaccine could also induce an accumulation of Treg cells in patients with mixed cryoglobulinemia vasculitis (MCV), who have a defciency of Treg cells (2) and in healthy individuals. We also investigated immunologic variables possibly associated with a low immunogenic-ity of SARS-CoV-2 mRNA vaccine in patients with MCV (3).Methods:
We analyzed peripheral blood lymphocyte subpopulations and anti-SARS-CoV-2 serological response in 24 patients with MCV and 9 Healthy donors (HD) before and after 2 weeks after the second dose of the Pfzer/BioNTech vaccine.Results:
Among MCV patients we found 15 serological responders and 9 non-responders. All 5 seronegative patients treated recently with rituximab had <5 B cells/μ L, whereas the absolute B cell count was increased in 2 of 4 untreated patients due to monoclonal B cell lymphocytosis, with monoclonal cells representing more than 90% of B cells, associated with non-Hodgkin lymphoma. The percentage of pathologic CD21low B cells was signifcantly increased in seronegative patients. Before receiving the Pfzer/BioNTech vaccine, patients with MCV had a signifcantly reduced frequency of Treg cells among CD4+ T cells compared to HD. After the second dose of the vaccine, there was in MCV patients a signifcant increase in the percent and absolute count of Treg among CD4+ T cells Concerning the pre-vaccination distribution of T cells subpopulations, including the percentages and absolute counts of total CD3+, CD4+, CD8+, HLA-DR+ activated, Treg or CD56+ natural killer T cells, we could not reveal any pattern signifcantly associated with lack of serological response to vaccine.Conclusion:
Our fndings show that lack of immunoreactivity in patients with MCV may be associated with expansion of pathologic B cells and that anti-SARS-CoV2 mRNA vaccine may induce an increase of Treg cells.
atreg; CD3 antigen; CD4 antigen; complement component C3d receptor; endogenous compound; HLA DR antigen; rituximab; RNA vaccine; SARS-CoV-2 vaccine; adult; B lymphocyte; cancer patient; CD4+ T lymphocyte; cell count; clinical article; conference abstract; controlled study; cryoglobulinemia; drug therapy; female; human; human cell; immunoreactivity; lymphocyte subpopulation; male; monoclonal b cell lymphocytosis; natural killer T cell; nonhodgkin lymphoma; nonhuman; peripheral lymphocyte; regulatory T lymphocyte; Severe acute respiratory syndrome coronavirus 2; T lymphocyte subpopulation; vaccination; vasculitis
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Experimental Studies
Topics:
Vaccines
Language:
English
Journal:
Annals of the Rheumatic Diseases
Year:
2022
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS