CARDIOVASCULAR EVENTS in PATIENTS with RHEUMATOID ARTHRITIS: A TWO YEARS OBSERVATIONAL STUDY
Annals of the Rheumatic Diseases
; 81:1244, 2022.
Article
in English
| EMBASE | ID: covidwho-2009205
ABSTRACT
Background:
The risk of cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA) is higher than individuals from the general population due to chronic infammation. Current CV risk screening and management strategies underestimate the actual CV risk in RA. Thus, an adequate CV risk stratifcation has special relevance in RA to identify patients at risk of CV disease.Objectives:
To assess the incidence of cardiovascular events in a RA cohort after a 2 years follow-up.Methods:
A cohort study was performed in which inclusion criteria were adult RA patients and matched adults in terms of age, sex and CV risk factors (controls). Population over 75 years old, patients with established CV disease and/or stage III chronic kidney disease were excluded. Controls with other infam-matory diseases, pregnant women or any malignancy were also excluded. This study was performed from July-2019 to January-2022. CV risk assessment included risk factors collection and US evaluation consisted in detection of plaques and measurement of the intima-media thickness in both right and left carotid.Results:
Overall, a total of 200 cases and 111 healthy controls were enrolled in the study. Demographical and clinical variables were comparable between cases and controls and are shown in Table 1. US study revealed a higher IMT in both right and left carotid arteries with greater presence of plaques in patients than in controls (CI 95% [1.542;3.436], p<0.001). Plaques were found in both carotid arteries in the 32% of cases and 9.91% of controls. The longer duration of RA was related to a higher presence of carotid plaques (95% [1.015;1.056], p<0.001). Eight patients (4%) presented a cardiovascular event, and one of them died (0.5%). The events consisted in 2 angina pectoris, 3 transient ischemic attack, 1 acute myocardial infarction, 1 lacunar stroke and 1 cardiac arrest. Six out those 8 patients demonstrated bilateral plaque presence at baseline. Two patient caused loss of follow up due to death related to Covid-19. Not a single cardiovascular event was reported in the control group.Conclusion:
Our results shows that cardiovascular events are increased in RA patients and US study may be useful in predicting an event.
acute heart infarction; adult; angina pectoris; arterial wall thickness; cancer patient; cancer staging; cardiovascular disease; cardiovascular risk; carotid atherosclerosis; chronic kidney failure; clinical assessment; cohort analysis; conference abstract; controlled study; coronavirus disease 2019; female; follow up; heart arrest; human; incidence; lacunar stroke; major clinical study; male; malignant neoplasm; observational study; pregnant woman; rheumatoid arthritis; risk assessment; risk factor; transient ischemic attack
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Observational study
/
Prognostic study
Language:
English
Journal:
Annals of the Rheumatic Diseases
Year:
2022
Document Type:
Article
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