The association between mean platelet volume and poor outcome in patients with COVID-19: Systematic review, meta-analysis, and meta-regression
Journal of the Intensive Care Society
; 2022.
Article
in English
| EMBASE | ID: covidwho-2009322
ABSTRACT
Introduction:
This study aims to assess the association between mean platelet volume (MPV) and poor outcome in patients with COVID-19.Methods:
We performed a comprehensive literature search using the PubMed, Embase and Scopus databases with keywords “2019-nCoV” OR “SARS-CoV-2” OR “COVID-19” AND “mean platelet volume” OR “MPV” on 8 July 2021. The primary outcome was composite poor outcome, defined as severe COVID-19 or mortality. The pooled effect estimate was reported as mean differences in terms of MPV between the group with and without outcome.Results:
There were 17 studies which consist of 4549 patients with COVID-19 were included in this study. The incidence of poor outcome was 25% (20%–30%). Mean MPV was found to be higher in the poor outcome group in compare to no poor outcome group (10.3 ± 1.9 fL vs 9.9 ± 1.7 fL). The mean MPV difference between both group was 0.47 fL [95% CI 0.27, 0.67], p < 0.001;I2 62.91%, p < 0.001). In the sub-group analysis, patients with severe COVID-19 had higher MPV (mean difference 0.54 fL [95% CI 0.28, 0.80], p < 0.001;I2 54.84%, p = 0.014). Furthermore, MPV was also higher in the mortality group (mean difference 0.54 fL [95% CI 0.29, 0.80], p = 0.020;I2 71.11%, p = 0.004). Meta-regression analysis showed that the association between MPV and poor outcome was not affected by age (p = 0.789), gender (p = 0.167), platelets (p = 0.056), white blood cells (p = 0.639), and lymphocytes (p = 0.733).Conclusion:
This meta-analysis indicated that increased MPV was associated with severity and mortality in patients with COVID-19. Further research is needed to determine the optimum cut-off point.
adult; article; controlled study; coronavirus disease 2019; Embase; female; gender; human; human cell; incidence; leukocyte; lymphocyte; male; mean platelet volume; Medline; meta analysis; mortality; nonhuman; outcome assessment; Scopus; Severe acute respiratory syndrome coronavirus 2; systematic review
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Prognostic study
/
Reviews
/
Systematic review/Meta Analysis
Language:
English
Journal:
Journal of the Intensive Care Society
Year:
2022
Document Type:
Article
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