Baclofen Withdrawal-Induced Psychosis in the Setting of Renal Insufficiency.
J Investig Med High Impact Case Rep
; 10: 23247096221110402, 2022.
Article
in English
| MEDLINE | ID: covidwho-2009335
ABSTRACT
Baclofen is used to treat muscle spasticity, acting at GABA B receptors in the central nervous system. The abrupt cessation of baclofen causes baclofen withdrawal-induced psychosis. The risk is exacerbated if the patient has renal insufficiency or if the drug has been taken for a long time at high doses. Gradual tapering of baclofen usually does not produce symptomatic adverse effects. However, abrupt termination of the drug, especially in an inpatient hospital setting, can lead to symptoms such as increased spasticity, agitation, confusion, hallucinations, and seizures. We present a case of a patient who initially presented with seizures and experienced hallucinations after abrupt cessation of the medication. She had baseline chronic kidney disease but presented with acute worsening of her renal function. Impaired renal function decreases baclofen clearance and causes increased concentration of baclofen in circulation. This put the patient at higher risk of developing baclofen withdrawal, even at a lower dose.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Psychotic Disorders
/
Substance Withdrawal Syndrome
/
Renal Insufficiency
Type of study:
Case report
/
Prognostic study
Topics:
Long Covid
Limits:
Female
/
Humans
Language:
English
Journal:
J Investig Med High Impact Case Rep
Year:
2022
Document Type:
Article
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