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Evaluation of alpaca tracheal explants as an ex vivo model for the study of Middle East respiratory syndrome coronavirus (MERS-CoV) infection.
Te, Nigeer; Rodon, Jordi; Creve, Rhea; Pérez, Mónica; Segalés, Joaquim; Vergara-Alert, Júlia; Bensaid, Albert.
  • Te N; Unitat Mixta d'investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), 08193, Bellaterra, Catalonia, Spain.
  • Rodon J; IRTA, Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), 08193, Bellaterra, Catalonia, Spain.
  • Creve R; School of Public Health, Li Ka Shing, Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
  • Pérez M; Unitat Mixta d'investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), 08193, Bellaterra, Catalonia, Spain.
  • Segalés J; IRTA, Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), 08193, Bellaterra, Catalonia, Spain.
  • Vergara-Alert J; Unitat Mixta d'investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), 08193, Bellaterra, Catalonia, Spain.
  • Bensaid A; IRTA, Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), 08193, Bellaterra, Catalonia, Spain.
Vet Res ; 53(1): 67, 2022 Sep 02.
Article in English | MEDLINE | ID: covidwho-2009459
ABSTRACT
Middle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to public health. Here, we established an ex vivo alpaca tracheal explant (ATE) model using an air-liquid interface culture system to gain insights into MERS-CoV infection in the camelid lower respiratory tract. ATE can be infected by MERS-CoV, being 103 TCID50/mL the minimum viral dosage required to establish a productive infection. IFNs and antiviral ISGs were not induced in ATE cultures in response to MERS-CoV infection, strongly suggesting that ISGs expression observed in vivo is rather a consequence of the IFN induction occurring in the nasal mucosa of camelids.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Camelids, New World / Coronavirus Infections / Middle East Respiratory Syndrome Coronavirus Type of study: Experimental Studies Limits: Animals Language: English Journal: Vet Res Journal subject: Veterinary Medicine Year: 2022 Document Type: Article Affiliation country: S13567-022-01084-3

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Camelids, New World / Coronavirus Infections / Middle East Respiratory Syndrome Coronavirus Type of study: Experimental Studies Limits: Animals Language: English Journal: Vet Res Journal subject: Veterinary Medicine Year: 2022 Document Type: Article Affiliation country: S13567-022-01084-3