Your browser doesn't support javascript.
An Insight to Heat Shock Protein 90: A Remedy for Multiple Problems.
Yadav, Megha; Singh, Ankit Kumar; Kumar, Adarsh; Thareja, Suresh; Kumar, Pradeep.
  • Yadav M; Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda 151401, India.
  • Singh AK; Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda 151401, India.
  • Kumar A; Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda 151401, India.
  • Thareja S; Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda 151401, India.
  • Kumar P; Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda 151401, India.
Curr Pharm Des ; 28(32): 2664-2676, 2022.
Article in English | MEDLINE | ID: covidwho-2009796
ABSTRACT
Heat shock protein 90 (Hsp90) is a chaperone protein that prevents many other proteins from aggregating by folding them in a certain way. Hsp90 consists of three structural domains N-terminal, middle and C-terminal domains. Hsp90 has many activities in numerous proteins and signaling pathways like chimeric fusion proteins, steroid hormone receptors, tumor suppressor genes, and cell cycle regulatory proteins. The role of Hsp90 is not only in cancer but also in other diseases like COVID-19, leishmaniasis, diabetes, flavi virus, systemic sclerosis, grass carp reovirus, psoriasis, malaria, cardiac fibrosis, and alcohol-related liver diseases. This review is a compilation of the pharmacological profile of Hsp90 inhibitors, problems associated with them, and suggested remedies for the same.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Benzoquinones / COVID-19 Limits: Humans Language: English Journal: Curr Pharm Des Journal subject: Pharmacy Year: 2022 Document Type: Article Affiliation country: 1381612828666220829120630

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Benzoquinones / COVID-19 Limits: Humans Language: English Journal: Curr Pharm Des Journal subject: Pharmacy Year: 2022 Document Type: Article Affiliation country: 1381612828666220829120630