An Insight to Heat Shock Protein 90: A Remedy for Multiple Problems.
Curr Pharm Des
; 28(32): 2664-2676, 2022.
Article
in English
| MEDLINE | ID: covidwho-2009796
ABSTRACT
Heat shock protein 90 (Hsp90) is a chaperone protein that prevents many other proteins from aggregating by folding them in a certain way. Hsp90 consists of three structural domains N-terminal, middle and C-terminal domains. Hsp90 has many activities in numerous proteins and signaling pathways like chimeric fusion proteins, steroid hormone receptors, tumor suppressor genes, and cell cycle regulatory proteins. The role of Hsp90 is not only in cancer but also in other diseases like COVID-19, leishmaniasis, diabetes, flavi virus, systemic sclerosis, grass carp reovirus, psoriasis, malaria, cardiac fibrosis, and alcohol-related liver diseases. This review is a compilation of the pharmacological profile of Hsp90 inhibitors, problems associated with them, and suggested remedies for the same.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Benzoquinones
/
COVID-19
Limits:
Humans
Language:
English
Journal:
Curr Pharm Des
Journal subject:
Pharmacy
Year:
2022
Document Type:
Article
Affiliation country:
1381612828666220829120630
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