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Evaluation of the potential of Rejuveinix plus dexamethasone against sepsis.
Uckun, Fatih M; Saeed, Muhammad; Awili, Mustafa; Ozercan, Ibrahim H; Qazi, Sanjive; Lee, Cynthia; Shibli, Adeel; Skolnick, Alan W; Prusmack, Alonso; Varon, Joseph; Barrera, Cesar Ip; Orhan, Cemal; Volk, Michael; Sahin, Kazim.
  • Uckun FM; Drug Discovery Program, Reven Pharmaceuticals, Westminster, CO 80234, USA.
  • Saeed M; Department of Developmental Therapeutics, Immunology & Integrative Medicine, Ares Pharmaceuticals, St Paul, MN 55110, USA.
  • Awili M; PRX Research & Dallas Regional Medical Center, Dallas, TX 75149, USA.
  • Ozercan IH; PRX Research & Dallas Regional Medical Center, Dallas, TX 75149, USA.
  • Qazi S; Department of Pathology Faculty of Medicine, Firat University, Elazig, 23119, Turkey.
  • Lee C; Department of Developmental Therapeutics, Immunology & Integrative Medicine, Ares Pharmaceuticals, St Paul, MN 55110, USA.
  • Shibli A; Drug Discovery Program, Reven Pharmaceuticals, Westminster, CO 80234, USA.
  • Skolnick AW; PRX Research & Dallas Regional Medical Center, Dallas, TX 75149, USA.
  • Prusmack A; Memorial Hermann Memorial City Medical Center, Houston, TX 77024, USA; HD Research, Bellaire, TX 77401, USA.
  • Varon J; United Memorial Medical Center, Houston, TX 77091, USA.
  • Barrera CI; United Memorial Medical Center, Houston, TX 77091, USA.
  • Orhan C; United Memorial Medical Center, Houston, TX 77091, USA.
  • Volk M; Department of Animal Nutrition, Faculty of Veterinary, Firat University, Elazig, 23119, Turkey.
  • Sahin K; Drug Discovery Program, Reven Pharmaceuticals, Westminster, CO 80234, USA.
Future Microbiol ; 17: 1217-1229, 2022 10.
Article in English | MEDLINE | ID: covidwho-2009815
ABSTRACT

Aim:

Our main objectives were to compare the effects of Rejuveinix (RJX), dexamethasone (DEX) and their combination on the severity of sepsis and survival outcome in an animal model of fatal sepsis.

Methods:

We used the LPS plus D-galactosamine mouse model of sepsis to compare the anti-inflammatory activities of RJX, dexamethasone and a combination of RJX plus DEX. Additionally, we examined the clinical feasibility and tolerability of combining RJX with DEX in COVID-19 patients in a clinical phase I study. Data were analyzed using standard methods. Results &

conclusion:

RJX exhibited potent anti-inflammatory activity in the murine sepsis model. The combination of RJX plus DEX was more effective than either agent alone, decreased the inflammatory cytokine responses and associated organ damage, and improved the survival outcome in mice. In the phase I clinical study, RJX plus DEX was well tolerated by COVID-19 patients.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Sepsis / COVID-19 Drug Treatment / Anti-Inflammatory Agents Type of study: Experimental Studies / Prognostic study Limits: Animals Language: English Journal: Future Microbiol Journal subject: Microbiology Year: 2022 Document Type: Article Affiliation country: Fmb-2022-0044

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Sepsis / COVID-19 Drug Treatment / Anti-Inflammatory Agents Type of study: Experimental Studies / Prognostic study Limits: Animals Language: English Journal: Future Microbiol Journal subject: Microbiology Year: 2022 Document Type: Article Affiliation country: Fmb-2022-0044