Advances in application of single-cell RNA sequencing in cardiovascular research.
Front Cardiovasc Med
; 9: 905151, 2022.
Article
in English
| MEDLINE | ID: covidwho-2009850
ABSTRACT
Single-cell RNA sequencing (scRNA-seq) provides high-resolution information on transcriptomic changes at the single-cell level, which is of great significance for distinguishing cell subtypes, identifying stem cell differentiation processes, and identifying targets for disease treatment. In recent years, emerging single-cell RNA sequencing technologies have been used to make breakthroughs regarding decoding developmental trajectories, phenotypic transitions, and cellular interactions in the cardiovascular system, providing new insights into cardiovascular disease. This paper reviews the technical processes of single-cell RNA sequencing and the latest progress based on single-cell RNA sequencing in the field of cardiovascular system research, compares single-cell RNA sequencing with other single-cell technologies, and summarizes the extended applications and advantages and disadvantages of single-cell RNA sequencing. Finally, the prospects for applying single-cell RNA sequencing in the field of cardiovascular research are discussed.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Language:
English
Journal:
Front Cardiovasc Med
Year:
2022
Document Type:
Article
Affiliation country:
Fcvm.2022.905151
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