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Diabetic Ketoacidosis Was Associated with High Morbidity and Mortality in Hospitalized Patients with COVID-19 in the NYC Public Health System
Diabetology ; 3(3):477-493, 2022.
Article in English | MDPI | ID: covidwho-2009972
ABSTRACT

Background:

COVID-19 has been associated with a higher risk of death in patients with diabetes mellitus (DM). However, there is a dearth of data regarding the effects of diabetic ketoacidosis (DKA) in these patients. We explored the in-hospital outcomes of patients who presented with COVID-19 and DKA.

Methods:

A propensity score-matched observational retrospective cohort study was conducted in hospitalized patients with COVID-19 in the public healthcare system of New York City from 1 March 2020 to 31 October 2020. Patients were matched, and a subgroup analysis of patients with DKA and COVID-19 and patients without COVID-19 was conducted.

Results:

13,333 (16.0%) patients with COVID-19 and 70,005 (84.0%) without COVID-19 were included in the analysis. The in-hospital mortality rate was seven-fold in patients with DKA and COVID-19 compared to patients with COVID-19 and without DKA (80 (36.5%) vs. 11 (5.4%), p < 0.001). Patients with COVID-19 and DKA had a two-fold higher likelihood for in-hospital death (OR 1.95;95% CI 1.41–2.70;p < 0.001) after adjusting for multiple variables.

Conclusions:

DKA was associated with significantly higher in-hospital mortality in hospitalized patients with COVID-19.

Full text: Available Collection: Databases of international organizations Database: MDPI Type of study: Cohort study / Observational study / Prognostic study Language: English Journal: Diabetology Year: 2022 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: MDPI Type of study: Cohort study / Observational study / Prognostic study Language: English Journal: Diabetology Year: 2022 Document Type: Article