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Usefulness of the C2HEST Score in Predicting the Clinical Outcomes of COVID-19 in Diabetic and Non-Diabetic Cohorts.
Gajecki, Damian; Doroszko, Adrian; Trocha, Malgorzata; Giniewicz, Katarzyna; Kujawa, Krzysztof; Skarupski, Marek; Gawrys, Jakub; Matys, Tomasz; Szahidewicz-Krupska, Ewa; Rola, Piotr; Stachowska, Barbara; Halupczok-Zyla, Jowita; Adamik, Barbara; Kaliszewski, Krzysztof; Kilis-Pstrusinska, Katarzyna; Letachowicz, Krzysztof; Matera-Witkiewicz, Agnieszka; Pomorski, Michal; Protasiewicz, Marcin; Madziarski, Marcin; Konikowska, Klaudia; Remiorz, Agata; Orlowska, Maja; Proc, Krzysztof; Szymala-Pedzik, Malgorzata; Zorawska, Joanna; Lindner, Karolina; Sokolowski, Janusz; Jankowska, Ewa A; Madziarska, Katarzyna.
  • Gajecki D; Clinical Department of Internal Medicine, Hypertension and Clinical Oncology, Faculty of Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland.
  • Doroszko A; Clinical Department of Internal Medicine, Hypertension and Clinical Oncology, Faculty of Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland.
  • Trocha M; Department of Pharmacology, Faculty of Medicine, Wroclaw Medical University, Mikulicz-Radecki Street 2, 50-345 Wroclaw, Poland.
  • Giniewicz K; Statistical Analysis Centre, Wroclaw Medical University, K. Marcinkowski Street 2-6, 50-368 Wroclaw, Poland.
  • Kujawa K; Statistical Analysis Centre, Wroclaw Medical University, K. Marcinkowski Street 2-6, 50-368 Wroclaw, Poland.
  • Skarupski M; Faculty of Pure and Applied Mathematics, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego Street 27, 50-370 Wroclaw, Poland.
  • Gawrys J; Clinical Department of Internal Medicine, Hypertension and Clinical Oncology, Faculty of Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland.
  • Matys T; Clinical Department of Internal Medicine, Hypertension and Clinical Oncology, Faculty of Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland.
  • Szahidewicz-Krupska E; Clinical Department of Internal Medicine, Hypertension and Clinical Oncology, Faculty of Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland.
  • Rola P; Department of Cardiology, Provincial Specialized Hospital, Iwaszkiewicza 5 Street, 59-220 Legnica, Poland.
  • Stachowska B; Department of Endocrinology, Diabetes and Isotope Therapy, Faculty of Medicine, Wroclaw Medical University, Ludwik Pasteur 4, 50-367 Wroclaw, Poland.
  • Halupczok-Zyla J; Department of Endocrinology, Diabetes and Isotope Therapy, Faculty of Medicine, Wroclaw Medical University, Ludwik Pasteur 4, 50-367 Wroclaw, Poland.
  • Adamik B; Clinical Department of Anaesthesiology and Intensive Therapy, Faculty of Medicine, Wroclaw Medical University, Borowska Street 213, 50-556 Wroclaw, Poland.
  • Kaliszewski K; Department of General, Minimally Invasive and Endocrine Surgery, Faculty of Medicine, Wroclaw Medical University, Borowska Street 213, 50-556 Wroclaw, Poland.
  • Kilis-Pstrusinska K; Clinical Department of Paediatric Nephrology, Faculty of Medicine, Wroclaw Medical University, Borowska Street 213, 50-556 Wroclaw, Poland.
  • Letachowicz K; Clinical Department of Nephrology and Transplantation Medicine, Faculty of Medicine, Wroclaw Medical University, Borowska Street 213, 50-556 Wroclaw, Poland.
  • Matera-Witkiewicz A; Laboratory of Biological Activity Tests and Collection of Biological Material, Wroclaw Medical University, Borowska Street 211A, 50-556 Wroclaw, Poland.
  • Pomorski M; Clinical Department of Gynecology and Obstetrics, Faculty of Medicine, Wroclaw Medical University, Borowska Street 213, 50-556 Wroclaw, Poland.
  • Protasiewicz M; Clinical Department and Clinic of Cardiology, Wroclaw Medical University, Borowska Street 213, 50-556 Wroclaw, Poland.
  • Madziarski M; Clinical Department of Rheumatology and Internal Medicine, Faculty of Medicine, Wroclaw Medical University, Borowska Street 213, 50-556 Wroclaw, Poland.
  • Konikowska K; Department of Dietetics, Wroclaw Medical University, Parkowa Street 34, 51-616 Wroclaw, Poland.
  • Remiorz A; Clinical Department of Nephrology and Transplantation Medicine, Wroclaw University Hospital, Borowska Street 213, 50-556 Wroclaw, Poland.
  • Orlowska M; Department of Emergency Medicine, Wroclaw University Hospital, Borowska Street 213, 50-556 Wroclaw, Poland.
  • Proc K; Clinical Department of Rheumatology and Internal Medicine, Wroclaw University Hospital, Borowska Street 213, 50-556 Wroclaw, Poland.
  • Szymala-Pedzik M; Clinical Department of Geriatrics, Wroclaw Medical University, Pasteur 4 Street, 50-367 Wroclaw, Poland.
  • Zorawska J; Clinical Department of Geriatrics, Wroclaw Medical University, Pasteur 4 Street, 50-367 Wroclaw, Poland.
  • Lindner K; Clinical Department of Geriatrics, Wroclaw Medical University, Pasteur 4 Street, 50-367 Wroclaw, Poland.
  • Sokolowski J; Department of Emergency Medicine, Faculty of Medicine, Wroclaw Medical University, Borowska Street 213, 50-556 Wroclaw, Poland.
  • Jankowska EA; Institute of Heart Diseases, Wroclaw Medical University, Borowska Street 213, 50-556 Wroclaw, Poland.
  • Madziarska K; Institute of Heart Diseases, University Hospital in Wroclaw, Borowska Street 213, 50-556 Wroclaw, Poland.
J Clin Med ; 11(3)2022 Feb 07.
Article in English | MEDLINE | ID: covidwho-2010135
ABSTRACT

BACKGROUND:

Diabetes mellitus is among the most frequent comorbidities worsening COVID-19 outcome. Nevertheless, there are no data regarding the optimal risk stratification of patients with diabetes and COVID-19. Since individual C2HEST components reflect the comorbidities, we assumed that the score could predict COVID-19 outcomes. MATERIAL AND

METHODS:

A total of 2184 medical records of patients hospitalized for COVID-19 at the medical university center were analyzed, including 473 diabetic patients and 1666 patients without any glucose or metabolic abnormalities. The variables of patients' baseline characteristics were retrieved to calculate the C2HEST score and subsequently the diabetic and non-diabetic subjects were assigned to the following categories low-, medium- or high-risk. The measured outcomes included in-hospital mortality; 3-month and 6-month all-cause mortality; non-fatal end of hospitalization (discharged home/sudden-deterioration/rehabilitation) and adverse in-hospital clinical events.

RESULTS:

A total of 194 deaths (41%) were reported in the diabetic cohort, including 115 in-hospital deaths (24.3%). The 3-month and 6-month in-hospital mortality was highest in the high-risk C2HEST stratum. The C2HEST score revealed to be more sensitive in non-diabetic-group. The estimated six-month survival probability for high-risk subjects reached 0.4 in both cohorts whereas for the low-risk group, the six-month survival probability was 0.7 in the diabetic vs. 0.85 in the non-diabetic group-levels which were maintained during whole observation period. In both cohorts, receiver operating characteristics revealed that C2HEST predicts the following cardiogenic shock; acute heart failure; myocardial injury; and in-hospital acute kidney injury.

CONCLUSIONS:

We demonstrated the usefulness and performance of the C2HEST score in predicting the adverse COVID-19 outcomes in hospitalized diabetic subjects.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Jcm11030873

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Jcm11030873