Diffuse alveolar hemorrhage as a life threatening manifestation of newly diagnosed granulomatosis with polyangiitis following COVID-19 infection - a case report.
Vnitr Lek
; 68(5): 290-294, 2022.
Article
in English
| MEDLINE | ID: covidwho-2010607
ABSTRACT
A case report of a patient with newly diagnosed granulomatosis with polyangiitis (GPA) after undergoing COVID-19 (Coronavirus Disease 2019) is discussed. GPA is one of the ANCA-associated vasculitis, which is characterized by the presence of autoantibodies against cytoplasmic enzymes neutrophils (Anti Neutrophil Cytoplasmatic Antibodies). It is a vasculitis that mainly affects small blood vessels, leading to damage to the kidneys, lungs, and upper respiratory tract, including the paranasal sinuses and orbits. This disease can result in an acute life-threatening condition. Such complications include diffuse alveolar hemorrhage (DAH), a condition characterized by blood leakage from the pulmonary vessels into the alveoli, often leading to acute vital signs and even respiratory failure. DAH can have many causes - autoimmune diseases including vasculitides as well as non-immunological causes. Early and adequate comprehensive therapy including immunosuppressive treatment (cyclophosphamide/rituximab and glucocorticoids) can be life-saving.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Granulomatosis with Polyangiitis
/
COVID-19
/
Lung Diseases
Type of study:
Case report
/
Diagnostic study
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Vnitr Lek
Year:
2022
Document Type:
Article
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