Progress of research on changes of cellular immunity after SARS-CoV-2 infection
Chinese Journal of Nosocomiology
; 32(10):1590-1595, 2022.
Article
in English, Chinese
| GIM | ID: covidwho-2011224
ABSTRACT
The major causes of death of patients with COVID-19 include metabolic acidosis, septic shock, pulmonary edema, multiple organ failure and deep venous thrombosis. These systemic manifestations are associated with severe pathological damages of vital organs like lung and kidney that are caused by inflammatory storms. The occurrence, development and deterioration of disease is closely associated with the immune imbalance mechanisms such as disorder of lymphocyte subsets and emergence of cytokine storm. The cellular immunity plays a vital role. The expression levels of some blood inflammatory factors of the severe COVID-19 patients are remarkably elevated, IL-6 is a typical proinflammatory factor that causes the cytokine storm, which can be used for prediction of prognosis. IL-6 blockade may be an effective method to block the cytokine storm.
viral diseases; severe infections; prognostic markers; prognosis; lymphocytes; interleukin 6; inflammation; immunity; human diseases; cytokines; coronavirus disease 2019; cell mediated immunity; blood; acute infections; Severe acute respiratory syndrome coronavirus 2; man; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; viral infections; SARS-CoV-2; cellular immunity
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Collection:
Databases of international organizations
Database:
GIM
Language:
English
/
Chinese
Journal:
Chinese Journal of Nosocomiology
Year:
2022
Document Type:
Article
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