Expression of TNF-a, IFN-?, sIL-2R and CRP in COPD patients complicated with pulmonary tuberculosis
Chinese Journal of Nosocomiology
; 32(6):875-879, 2022.
Article
in English, Chinese
| GIM | ID: covidwho-2011588
ABSTRACT
OBJECTIVE:
To explore the expression of tumor necrosis factor-a (TNF-a), interferon-? (IFN-?), soluble interleukin-2 receptor (sIL-2 R) and C-reactive protein (CRP) in chronic obstructive pulmonary disease (COPD) patients complicated with pulmonary tuberculosis (PTB).METHODS:
From Mar 2016 to Mar 2019, the acute stage of COPD patients complicated with active stage of PTB who were treated in the department of respiratory and critical care medicine of the People's Hospital of Liangping District, Chongqing were assigned as the group, the acute stage of COPD patients complicated with recovery stage of PTB were assigned as the group B, the stable stage of COPD patients complicated with active stage of PTB were assigned as the group C, and the stable stage of COPD patients complicated with recovery stage of PTB were assigned as the group D. 25 patients with simple stable stage of COPD, 25 patients with simple recovery stage of PTB, 25 patients with simple acute stage of COPD, 25 patients with simple active stage of PTB and 25 people who received physical examination were chosen as the control group. The serum TNF-a, IFN-?, sIL-2 R and CRP were observed and compared among the groups, and the data were statistically analyzed.RESULTS:
The levels of TNF-a, IFN-?, sIL-2 R and CRP of the case groups were significantly higher than those of the control group (P < 0.05). The levels of serum TNF-a, IFN-?, sIL-2 R and CRP of the simple stable stage of COPD group, the simple acute stage of COPD group, the simple recovery stage of PTB group, the simple active stage of PTB group, the group D, the group B, the group C and the group A were elevated successively (P < 0.05). The levels of serum TNF-a, IFN-?, sIL-2 R and CRP of the patients with improved illness condition were reduced after treatment. The AUCs of the TNF-a, IFN-?, sIL-2 R and CRP were respectively 0.706, 0.718, 0.768 and 0.807 in prediction of deterioration of disease.CONCLUSION:
The PTB patients complicated with COPD show abnormal expression of serum TNF-a, IFN-?, sIL-2 R and CRP. The TNF-a, IFN-?, sIL-2 R and CRP are associated with the severity of disease and have high value in prediction of the deterioration of disease.
9007-41-4; 308079-78-9; 102524-44-7; 85898-30-2; chronic obstructive pulmonary disease; respiratory diseases; C-reactive protein; human diseases; tumour necrosis factor; blood serum; patients; interleukin 2; lungs; chronic diseases; tuberculosis; antituberculous agents; bacterial diseases; blood analysis; clinical aspects; disease course; drug therapy; medical treatment; regimens; man; Severe acute respiratory syndrome coronavirus 2; Mycobacterium tuberculosis; Chongqing; China; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; South Western China; APEC countries; East Asia; Asia; high Human Development Index countries; upper-middle income countries; Mycobacterium; Mycobacteriaceae; Corynebacterineae; Actinomycetales; Actinobacteridae; Actinobacteria; Bacteria; prokaryotes; lung diseases; cachectin; cachexin; tumor necrosis factor; SARS-CoV-2; Chongqing Shi; People's Republic of China; bacterial infections; bacterioses; bacterium; clinical picture; disease progression; chemotherapy
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Collection:
Databases of international organizations
Database:
GIM
Language:
English
/
Chinese
Journal:
Chinese Journal of Nosocomiology
Year:
2022
Document Type:
Article
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