ULTRASENSITIVE AND RAPID DETECTION OF COVID-19 VIRUS USING DUAL-CLAMPED SURFACE-ENHANCED-RAMAN-SCATTERING NANOSENSORS
25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
; : 835-836, 2021.
Article
in English
| Scopus | ID: covidwho-2011687
ABSTRACT
The COVID-19 outbreak spreads around world, accumulated to more than 27 million confirmed cases and 800k deaths. Polymerase Chain Reaction (PCR), a gold-standard diagnostic method, were labor intensive, time-consuming and costly, which restricted its application to widespread screening. Herein, this study purposes a one-pot and non-washing method to rapidly detect virus by dual-clamped surface-enhanced Raman scattering (SERS) mechanism. COVID Antigens were captured by SERS nanoparticles and novel SERS substrate simultaneously to achieve 6 order enhancements within 20 minutes. The dual-SERS sensors have reached a detection limit of 1 ng/ml in clinical samples for recognizing nucleocapsid & Spike proteins of COVID-19, which is comparable with PCR results. © 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.
antibody; COVID-19 virus; dual-clamped SERS; rapid diagnosis; virus antigen test; Antibodies; Antigens; Chemical detection; Nanosensors; Polymerase chain reaction; Raman scattering; Substrates; Surface scattering; Viruses; Diagnostic methods; Dual-clamped surface-enhanced raman scattering; Enhanced Raman scattering; Gold standards; Rapid detection; Rapid diagnose; Surface enhanced Raman; Ultrasensitive detection; COVID-19
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Databases of international organizations
Database:
Scopus
Language:
English
Journal:
25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
Year:
2021
Document Type:
Article
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