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Fully autonomous domino capillaric circuit for instrument-free, quantitative detection of SARS-CoV-2 in saliva
25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 ; : 153-154, 2021.
Article in English | Scopus | ID: covidwho-2012239
ABSTRACT
Rapid, sensitive, quantitative and patient-friendly diagnostic tools have yet to be developed for COVID-19 continued monitoring at the point-of-care. Here, we present an instrument-free capillary microfluidic chip coupled to a lateral flow module that is compatible with a smartphone application for quantitative detection of SARS-CoV-2 from saliva samples. The microfluidic chip is fully autonomous, and performs aliquoting, sample metering, and sequential delivery of reagents. The limit of detection is 0.07 ng/mL for recombinant nucleocapsid protein in saliva. This rapid antigen test provides results in less than 1 hour, without sacrificing analytical sensitivity. © 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.
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Collection: Databases of international organizations Database: Scopus Language: English Journal: 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 Year: 2021 Document Type: Article

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Collection: Databases of international organizations Database: Scopus Language: English Journal: 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 Year: 2021 Document Type: Article