Fully autonomous domino capillaric circuit for instrument-free, quantitative detection of SARS-CoV-2 in saliva
25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
; : 153-154, 2021.
Article
in English
| Scopus | ID: covidwho-2012239
ABSTRACT
Rapid, sensitive, quantitative and patient-friendly diagnostic tools have yet to be developed for COVID-19 continued monitoring at the point-of-care. Here, we present an instrument-free capillary microfluidic chip coupled to a lateral flow module that is compatible with a smartphone application for quantitative detection of SARS-CoV-2 from saliva samples. The microfluidic chip is fully autonomous, and performs aliquoting, sample metering, and sequential delivery of reagents. The limit of detection is 0.07 ng/mL for recombinant nucleocapsid protein in saliva. This rapid antigen test provides results in less than 1 hour, without sacrificing analytical sensitivity. © 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.
capillary microfluidics; COVID-19; domino capillaric circuits; SARS-CoV-2; Fluidic devices; Microfluidics; Recombinant proteins; Timing circuits; Aliquoting; Capillary microfluidic; Diagnostics tools; Domino capillaric circuit; Lateral Flow; Microfluidic-chips; Point of care; Quantitative detection; Sequential delivery; Smart-phone applications; Coronavirus
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Collection:
Databases of international organizations
Database:
Scopus
Language:
English
Journal:
25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
Year:
2021
Document Type:
Article
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