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Impact of innate immunity, endothelial damage, and metabolic biomarkers on COVID-19 severity and mortality
Rocco, Joseph M.; Laghetti, Paola, Di Stefano, Mariantonietta, Sereti, Irini, Ortega-Villa, Ana, Wang, Jing, Rupert, Adam, Chironna, Maria, Ye, Peiying, Liu, Xiangdong, Anderson, Megan V.; Burbelo, Peter B.; Fiore, Jose Ramon, Saracino, Annalisa, Lisco, Andrea.
Open forum infectious diseases ; 2022.
Article in English | EuropePMC | ID: covidwho-2012411
ABSTRACT
In this study, abnormal levels of myeloid activation, endothelial damage and innate immune markers were associated with severe COVID-19, while higher levels of metabolic biomarkers (irisin, leptin), demonstrated a protective effect. These data support a model for COVID-19 immunopathogenesis linking robust inflammation and endothelial damage in metabolically-predisposed individuals.
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Collection: Databases of international organizations Database: EuropePMC Type of study: Experimental Studies / Prognostic study Language: English Journal: Open forum infectious diseases Year: 2022 Document Type: Article

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Collection: Databases of international organizations Database: EuropePMC Type of study: Experimental Studies / Prognostic study Language: English Journal: Open forum infectious diseases Year: 2022 Document Type: Article